Hong Yuling, Zhang Yunxing, Zhao Haibo, Chen Hailing, Yu Qing-Qing, Cui Hongxia
School of Clinical Medicine, Jining Medical University, Jining, China.
Jining First People's Hospital, Jining Medical College, Jining, China.
Front Cell Dev Biol. 2022 Nov 18;10:1051306. doi: 10.3389/fcell.2022.1051306. eCollection 2022.
Hepatocellular carcinoma (HCC) is the most frequent and deadly type of liver cancer. While the underlying molecular mechanisms are poorly understood, it is documented that lncRNAs may play key roles. Many HCC-associated lncRNAs have been linked to HBV and HCV infection, mediating gene expression, cell growth, development, and death. Studying the regulatory mechanisms and biological functions of HCC-related lncRNAs will assist our understanding of HCC pathogenesis as well as its diagnosis and management. Here, we address the potential of dysregulated lncRNAs in HCC as diagnostic and therapeutic biomarkers, and we evaluate the oncogenic or tumor-suppressive properties of these lncRNAs.
肝细胞癌（HCC）是最常见且致命的肝癌类型。尽管其潜在的分子机制尚不清楚，但有文献记载长链非编码RNA（lncRNAs）可能发挥关键作用。许多与HCC相关的lncRNAs已被证实与乙肝病毒（HBV）和丙肝病毒（HCV）感染有关，可介导基因表达、细胞生长、发育和死亡。研究与HCC相关的lncRNAs的调控机制和生物学功能，将有助于我们理解HCC的发病机制及其诊断和治疗。在此，我们探讨失调的lncRNAs在HCC中作为诊断和治疗生物标志物的潜力，并评估这些lncRNAs的致癌或抑癌特性。
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