Hao Jing, Zhao Pengfei
Department of Breast Surgery, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, Zhejiang 323000, China.
J Cancer Res Ther. 2015 Aug;11 Suppl 1:C59-62. doi: 10.4103/0973-1482.163841.
The relationship between methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms and lung cancer susceptibility is controversial according to the case-control or cohort study. We perform this meta-analysis to evaluate the association between MTHFR 677C>T polymorphisms and lung cancer risk based on Chinese Han population.
We searched the databases of Medline, PubMed, EMBASE, Wanfang, and CNIK to find the case-control or cohort study about the relationship between MTHFR 677C>T polymorphisms and lung cancer susceptibility. The genotype of CC, CT, and TT for the lung cancer patients and healthy controls were extracted and aggregated by meta-analysis method. The relationship between MTHFR 677C>T polymorphisms and lung cancer susceptibility was assessed by odds ratio (OR) and its 95% confidence interval (CI).
According to the inclusion and exclusion criteria, we finally included 14 case-control studies, with 2845 lung cancer patients and 3691 healthy controls in this meta-analysis. The pooled results showed the OR were 1.02 (95% CI: 0.93-1.13), 0.66 (95% CI: 0.60-0.73), and 1.25 (95% CI: 1.07-1.47) in recessive genetic model, dominant genetic model, and homozygous model, respectively.
Chinese Han people with TT/CT genotype of MTHFR gene may have increased the risk of developing breast cancer.
根据病例对照研究或队列研究，亚甲基四氢叶酸还原酶（MTHFR）677C>T多态性与肺癌易感性之间的关系存在争议。我们进行这项荟萃分析，以评估基于中国汉族人群的MTHFR 677C>T多态性与肺癌风险之间的关联。
我们检索了Medline、PubMed、EMBASE、万方和中国知网数据库，以查找关于MTHFR 677C>T多态性与肺癌易感性关系的病例对照研究或队列研究。通过荟萃分析方法提取并汇总肺癌患者和健康对照的CC、CT和TT基因型。通过比值比（OR）及其95%置信区间（CI）评估MTHFR 677C>T多态性与肺癌易感性之间的关系。
根据纳入和排除标准，我们最终纳入了14项病例对照研究，本荟萃分析中有2845例肺癌患者和3691例健康对照。汇总结果显示，隐性遗传模型、显性遗传模型和纯合子模型中的OR分别为1.02（95%CI：0.93-1.13）、0.66（95%CI：0.60-0.73）和1.25（95%CI：1.07-1.47）。
MTHFR基因TT/CT基因型的中国汉族人群患乳腺癌的风险可能增加。
