Yang Z, Wang X, Li S
Department of Emergency, Huaihe Hospital of Henan University, Kaifeng, Henan, China.
Indian J Cancer. 2015 Nov;52 Suppl 1:e26-8. doi: 10.4103/0019-509X.168952.
The aim of this meta-analysis was to assess the methylene tetrahydrofolate reductase (MTHFR) gene C677T polymorphisms and esophageal cancer susceptibility in Chinese Han population.
The databases of PubMed, MEDLINE, Wanfang, and CNIK was electronic searched to find the case-control or cohort study about the relationship between MTHFR gene C677T polymorphisms and esophageal cancer susceptibility in Chinese Han population. The odds ratio (OR) was used to assess the relationship between CC, CT, and TT genotype and esophageal cancer risk. The data were pooled using Stata 11.0 software.
Eight articles included 1752 esophageal cancer and 2363 controls were found and included in this meta-analysis. The pooled OR was 1.86 with its 95% confidence interval of 1.21-2.86 and 1.62 with its 95% confidence interval of 1.15-2.27 for TT versus CC and CT versus CC model which indicated that people with TT OR CT genotype significant increase the risk of developing esophageal cancer.
Esophageal cancer risk was significantly increased in people with TT/CT genotype of MTHFR gene.
本荟萃分析旨在评估亚甲基四氢叶酸还原酶（MTHFR）基因C677T多态性与中国汉族人群食管癌易感性之间的关系。
通过电子检索PubMed、MEDLINE、万方和中国知网数据库，查找关于中国汉族人群MTHFR基因C677T多态性与食管癌易感性之间关系的病例对照研究或队列研究。采用比值比（OR）评估CC、CT和TT基因型与食管癌风险之间的关系。使用Stata 11.0软件对数据进行汇总。
共纳入8篇文章，包括1752例食管癌患者和2363例对照，并纳入本荟萃分析。在TT与CC以及CT与CC模型中，合并OR分别为1.86，95%置信区间为1.21 - 2.86；1.62，95%置信区间为1.15 - 2.27，这表明TT或CT基因型的人群患食管癌的风险显著增加。
MTHFR基因TT/CT基因型的人群患食管癌的风险显著增加。
