Division of Pulmonary and Critical Care Medicine, Department of Medicine and Geriatrics, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Gene. 2013 Feb 15;515(1):214-9. doi: 10.1016/j.gene.2012.11.036. Epub 2012 Dec 10.
The association between methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and lung cancer risk has been studied in various populations with conflicting results. The aim of this study was to assess the association strength by a meta-analysis of published studies.
We searched PubMed and Chinese Biomedical (CBM) databases for relevant literatures published by July 18, 2012. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to assess the strength of the association.
A total of 20 studies comprising 11,653 cases and 12,032 controls were included in the final meta-analysis. Using the random effect model, we found that MTHFR 677TT variant genotype was associated with an increased lung cancer risk (OR=1.26, 95% CI=1.05-1.50, P=0.011 for TT vs. CC; OR=1.19, 95% CI=1.03-1.37, P<0.001 for TT vs. CC+CT; OR=1.11, 95% CI=1.02-1.22, P=0.017 for T allele vs. C allele). In the further stratified analyses, the increased lung cancer risk was found in Asian subjects (OR=1.31, 95% CI=1.01-1.71, P=0.045 for TT vs. CC; OR=1.17, 95% CI=1.00-1.38, P=0.048 for TT vs. CC+CT). There were no evidences for obvious publication bias in the overall meta-analysis and Asian subjects.
MTHFR 677TT genotype might increase the susceptibility of lung cancer, especially in Asians.
亚甲基四氢叶酸还原酶（MTHFR）677C>T 多态性与肺癌风险的关联在不同人群中进行了研究，但结果存在冲突。本研究的目的是通过对已发表研究的荟萃分析来评估关联强度。
我们检索了 PubMed 和中国生物医学文献数据库（CBM），截至 2012 年 7 月 18 日发表的相关文献。使用合并的比值比（OR）及其 95%置信区间（CI）来评估关联的强度。
共有 20 项研究（包括 11653 例病例和 12032 例对照）纳入最终的荟萃分析。采用随机效应模型，我们发现 MTHFR 677TT 变异基因型与肺癌风险增加相关（TT 与 CC 相比，OR=1.26，95%CI=1.05-1.50，P=0.011；TT 与 CC+CT 相比，OR=1.19，95%CI=1.03-1.37，P<0.001；T 等位基因与 C 等位基因相比，OR=1.11，95%CI=1.02-1.22，P=0.017）。进一步的分层分析显示，亚洲人群中肺癌风险增加（TT 与 CC 相比，OR=1.31，95%CI=1.01-1.71，P=0.045；TT 与 CC+CT 相比，OR=1.17，95%CI=1.00-1.38，P=0.048）。总体荟萃分析和亚洲人群均未发现明显的发表偏倚证据。
MTHFR 677TT 基因型可能增加肺癌的易感性，尤其在亚洲人群中。
