Ma Hailin, Wang Yan, Wu Jianhui, Luo Ping, Han Buxin
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
Sci Rep. 2015 Sep 1;5:13701. doi: 10.1038/srep13701.
To investigate the effects of high-altitude exposure on response inhibition, event-related potential (ERP) components N2 and P3 were measured in Go/NoGo task. The participants included an 'immigrant' high-altitude group (who had lived at high altitude for three years but born at low altitude) and a low-altitude group (living in low altitude only). Although the behavioural data showed no significant differences between the two groups, a delayed latency of NoGo-N2 was found in the high-altitude group compared to the low-altitude group. Moreover, larger N2 and smaller P3 amplitudes were found in the high-altitude group compared to the low-altitude group, for both the Go and NoGo conditions. These findings suggest that high-altitude exposure affects response inhibition with regard to processing speed during the conflict monitoring stage. In addition, high altitude generally increases the neural activity in the matching step of information processing and attentional resources. These results may provide some insights into the neurocognitive basis of the effects on high-altitude exposure on response inhibition.
为研究高原暴露对反应抑制的影响，在Go/NoGo任务中测量了事件相关电位（ERP）成分N2和P3。参与者包括一个“移民”高原组（出生于低海拔地区，但已在高海拔地区生活三年）和一个低海拔组（仅生活在低海拔地区）。尽管行为数据显示两组之间无显著差异，但与低海拔组相比，高原组的NoGo-N2潜伏期延迟。此外，在Go和NoGo条件下，与低海拔组相比，高原组均发现N2波幅更大，P3波幅更小。这些发现表明，高原暴露在冲突监测阶段影响了与处理速度相关的反应抑制。此外，高海拔通常会增加信息处理匹配步骤和注意力资源中的神经活动。这些结果可能为高原暴露对反应抑制影响的神经认知基础提供一些见解。
