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Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens.重症患者静脉注射多黏菌素 B 的群体药代动力学：剂量方案选择的意义。
Clin Infect Dis. 2013 Aug;57(4):524-31. doi: 10.1093/cid/cit334. Epub 2013 May 22.
2
A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies.一种经验证的超高效液相色谱-串联质谱法，用于定量检测小鼠血清和上皮衬液中的多粘菌素 B：在药代动力学研究中的应用。
J Antimicrob Chemother. 2013 May;68(5):1104-10. doi: 10.1093/jac/dks536. Epub 2013 Jan 22.
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Significance of protein binding in pharmacokinetics and pharmacodynamics.蛋白质结合在药代动力学和药效学中的意义。
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4
Pharmacokinetics of polymyxin B1 in patients with multidrug-resistant Gram-negative bacterial infections.多粘菌素B1在多重耐药革兰氏阴性菌感染患者中的药代动力学
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血清中多粘菌素B蛋白结合的分析及功能测定

Analytical and functional determination of polymyxin B protein binding in serum.

作者信息

Abodakpi Henrietta, Gohlke Jie, Chang Kai-Tai, Chow Diana S-L, Tam Vincent H

机构信息

Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, Texas, USA.

Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.

出版信息

Antimicrob Agents Chemother. 2015 Nov;59(11):7121-3. doi: 10.1128/AAC.01815-15. Epub 2015 Aug 31.

DOI:10.1128/AAC.01815-15
PMID:26324262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4604353/
Abstract

To enhance our understanding of the pharmacological properties of polymyxin B, serum protein binding for polymyxin B1, B2, and B3 and for isoleucine-polymyxin B1 was evaluated. Using equilibrium dialysis and ultrafiltration, comparable protein binding was found in all 4 components of polymyxin B (92% to 99%). Protein binding in human serum was further assessed using a functional assay, the results of which were in general agreement with previous findings (approximately 90%).

摘要

为了增强我们对多粘菌素B药理特性的理解，对多粘菌素B1、B2和B3以及异亮氨酸-多粘菌素B1的血清蛋白结合情况进行了评估。使用平衡透析和超滤法，发现多粘菌素B的所有4种组分中的蛋白结合情况相当（92%至99%）。使用功能测定法进一步评估了人血清中的蛋白结合情况，其结果与先前的发现总体一致（约90%）。