血清中多粘菌素B蛋白结合的分析及功能测定
Analytical and functional determination of polymyxin B protein binding in serum.
作者信息
Abodakpi Henrietta, Gohlke Jie, Chang Kai-Tai, Chow Diana S-L, Tam Vincent H
机构信息
Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, Texas, USA.
Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2015 Nov;59(11):7121-3. doi: 10.1128/AAC.01815-15. Epub 2015 Aug 31.
Abstract
To enhance our understanding of the pharmacological properties of polymyxin B, serum protein binding for polymyxin B1, B2, and B3 and for isoleucine-polymyxin B1 was evaluated. Using equilibrium dialysis and ultrafiltration, comparable protein binding was found in all 4 components of polymyxin B (92% to 99%). Protein binding in human serum was further assessed using a functional assay, the results of which were in general agreement with previous findings (approximately 90%).
摘要
为了增强我们对多粘菌素B药理特性的理解，对多粘菌素B1、B2和B3以及异亮氨酸-多粘菌素B1的血清蛋白结合情况进行了评估。使用平衡透析和超滤法，发现多粘菌素B的所有4种组分中的蛋白结合情况相当（92%至99%）。使用功能测定法进一步评估了人血清中的蛋白结合情况，其结果与先前的发现总体一致（约90%）。
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