对环丙沙星更高的耐受性作为大肠杆菌序列类型131的H30亚克隆大流行传播潜在的一种可能的可选择表型。
Greater ciprofloxacin tolerance as a possible selectable phenotype underlying the pandemic spread of the H30 subclone of Escherichia coli sequence type 131.
作者信息
Johnson James R, Porter Stephen B, Thuras Paul, Johnson Timothy J, Price Lance B, Tchesnokova Veronika, Sokurenko Evgeni V
机构信息
VA Medical Center, Minneapolis, Minnesota, USA University of Minnesota, Minneapolis-Saint Paul, Minnesota, USA
VA Medical Center, Minneapolis, Minnesota, USA.
出版信息
Antimicrob Agents Chemother. 2015 Nov;59(11):7132-5. doi: 10.1128/AAC.01687-15. Epub 2015 Aug 31.
Abstract
Minimum bactericidal concentrations (MBCs) for ciprofloxacin were significantly higher among 41 members of the H30 subclone within Escherichia coli sequence type 131 than among 48 other fluoroquinolone-resistant E. coli isolates. This MBC difference, which was not explained by ciprofloxacin MICs, gyrA, parC, and parE mutations, the presence of aac(6')-Ib-cr, or organic solvent tolerance (a surrogate for efflux pump activity), conceivably could have promoted the pandemic emergence of the H30 sequence type 131 subclone.
摘要
在大肠杆菌序列型131中的H30亚克隆的41个成员中，环丙沙星的最低杀菌浓度（MBCs）显著高于其他48株耐氟喹诺酮类大肠杆菌分离株。这种MBC差异无法用环丙沙星最低抑菌浓度（MICs）、gyrA、parC和parE突变、aac(6')-Ib-cr的存在或有机溶剂耐受性（外排泵活性的替代指标）来解释，这可能促进了H30序列型131亚克隆在全球的出现。
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