Hsia Daniel S, Larrivee Sandra, Cefalu William T, Johnson William D
Pennington Biomedical Research Center, Baton Rouge, LA
Pennington Biomedical Research Center, Baton Rouge, LA.
Diabetes Care. 2015 Nov;38(11):2166-8. doi: 10.2337/dc15-0299. Epub 2015 Aug 31.
This study estimated the screening prevalence of prediabetes and diabetes using a lower BMI cutoff of 23 kg/m(2) in Asians in the U.S. using the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2012.
A cross-sectional analysis was conducted of non-Hispanic Asians, aged 45 years and older, with available BMI, HbA1c, and fasting glucose data. These overall criteria were met by 341 participants.
Lowering the screening BMI to 23 kg/m(2) increased the sensitivity of screening for prediabetes and diabetes from 50.2 to 74.1% (P < 0.0001) but decreased the specificity from 62.9 to 38.7% (P < 0.0001).
Although this will add additional health care costs resulting from more widespread screening, early identification of these conditions may be beneficial for primary and secondary prevention in this unique population that develops prediabetes and diabetes at lower BMI levels.
本研究利用2011年至2012年的美国国家健康与营养检查调查（NHANES），对美国亚洲人群中体重指数（BMI）下限设定为23kg/m²时的糖尿病前期和糖尿病筛查患病率进行了估算。
对年龄在45岁及以上、有可用BMI、糖化血红蛋白（HbA1c）和空腹血糖数据的非西班牙裔亚洲人进行横断面分析。共有341名参与者符合这些总体标准。
将筛查BMI下限降至23kg/m²时，糖尿病前期和糖尿病筛查的灵敏度从50.2%提高到74.1%（P<0.0001），但特异度从62.9%降至38.7%（P<0.0001）。
尽管这会因更广泛的筛查导致额外的医疗保健费用增加，但对于在较低BMI水平下发生糖尿病前期和糖尿病的这一独特人群，早期识别这些病症可能有利于一级和二级预防。
