Pavić Ivan, Čepin-Bogović Jasna, Hojsak Iva
Children's Hospital Zagreb, Zagreb, Croatia.
Children's Hospital Zagreb, Zagreb, Croatia
Clin Pediatr (Phila). 2016 Jun;55(7):639-44. doi: 10.1177/0009922815603675. Epub 2015 Aug 30.
The aim of this study was to assess the association between chronic cough and acid or weakly acid gastroesophageal reflux (GER) determined by 24-hour multichannel intraluminal impedance-pH monitoring and to assess whether the association is age dependent. Overall 150 children (mean age 7.5 years; range 0.3-18.0 years; male/female 90/60) were enrolled. Median of 87.5% (0% to 100%) of all cough episodes were associated with reflux; 9% (0% to 100%) with acidic and 60% (0% to 100%) with weakly acidic episodes. In 52 children (34.7%), all cough episodes were associated with GER (100% association). Children younger than 2 years had significantly higher number of cough episodes associated with total (P = .03) and weakly acidic GER (P = .01). Binary logistic regression confirmed that only increase in age decreases the risk for complete (100%) association between cough episode and GER. Cough is significantly associated with weakly acidic GER and children of younger age are at higher risk.
本研究旨在评估通过24小时多通道腔内阻抗-pH监测确定的慢性咳嗽与酸或弱酸型胃食管反流（GER）之间的关联，并评估这种关联是否与年龄有关。总共纳入了150名儿童（平均年龄7.5岁；范围0.3 - 18.0岁；男/女90/60）。所有咳嗽发作中，中位数87.5%（0%至100%）与反流相关；9%（0%至100%）与酸性发作相关，60%（0%至100%）与弱酸型发作相关。在52名儿童（34.7%）中，所有咳嗽发作均与GER相关（关联度为100%）。2岁以下儿童与总GER（P = .03）和弱酸型GER相关的咳嗽发作次数显著更多（P = .01）。二元逻辑回归证实，只有年龄增加会降低咳嗽发作与GER之间完全（100%）关联的风险。咳嗽与弱酸型GER显著相关，年龄较小的儿童风险更高。
