气道反流与儿童非酸性反流的关系：综述。
The link between airway reflux and non-acid reflux in children: a review.
机构信息
University of Malaya, Faculty of Medicine, Department of Otorhinolaryngology, Wilayah Persekutuan Kuala Lumpur, Malaysia.
University of Malaya, Faculty of Medicine, Department of Otorhinolaryngology, Wilayah Persekutuan Kuala Lumpur, Malaysia.
出版信息
Braz J Otorhinolaryngol. 2023 Mar-Apr;89(2):329-338. doi: 10.1016/j.bjorl.2022.05.002. Epub 2022 May 21.
OBJECTIVE
Airway reflux, a member of extra-esophageal reflux, has been linked to countless respiratory pathologies amongst children. The advent of novel instrumentation has enabled the discovery of non-acid reflux which was postulated as the main culprit of airway reflux. The objective of this review is to outline the association between non-acid reflux and airway reflux in children.
METHODS
A comprehensive review of recent literature on non-acid reflux and airway reflux in children was conducted. Studies ranged from January 2010 till November 2021 were searched over a period of a month: December 2021.
RESULTS
A total of eleven studies were identified. All studies included in this review revealed a strong link between non-acid reflux and airway reflux in children. 6 of the included studies are prospective studies, 3 retrospective studies, 1 cross-section study, and type of study was not mentioned in 1 study. The most common reported respiratory manifestation of non-acid reflux in children was chronic cough (7 studies). Predominant non-acid reflux was noted in 4 studies. The total number of children in each study ranges from 21 to 150 patients. MII-pH study was carried out in all studies included as a diagnostic tool for reflux investigation.
CONCLUSION
Non-acid reflux is the culprit behind airway reflux as well as other myriads of extra-esophageal manifestations in children. Multicentre international studies with a standardized protocol could improve scientific knowledge in managing non-acid reflux in airway reflux amongst children.
目的
气道反流是一种食管外反流，与儿童无数呼吸道疾病有关。新型仪器的出现使人们发现了非酸性反流，这种反流被认为是气道反流的主要罪魁祸首。本综述的目的是概述非酸性反流与儿童气道反流之间的关系。
方法
对 2010 年 1 月至 2021 年 11 月期间儿童非酸性反流和气道反流的最新文献进行了全面综述。研究范围为一个月（2021 年 12 月）内搜索的 2010 年 1 月至 2021 年 11 月期间的研究。
结果
共确定了 11 项研究。本综述中纳入的所有研究都表明，儿童非酸性反流与气道反流之间存在很强的联系。纳入的研究中，有 6 项为前瞻性研究，3 项为回顾性研究，1 项为横断面研究，1 项研究未提及研究类型。儿童非酸性反流最常见的呼吸道表现是慢性咳嗽（7 项研究）。4 项研究中均发现主要为非酸性反流。每项研究中的儿童总数从 21 到 150 例不等。所有纳入的研究均进行了 MII-pH 研究作为反流研究的诊断工具。
结论
非酸性反流是气道反流以及儿童其他无数食管外表现的罪魁祸首。具有标准化方案的多中心国际研究可以提高管理儿童气道反流中非酸性反流的科学知识。
Zotero 插件