Mochizuki S, Yoshida A
Department of Agricultural Chemistry, Nagoya University, Japan.
J Nutr Sci Vitaminol (Tokyo). 1989 Oct;35(5):431-40. doi: 10.3177/jnsv.35.431.
Effects of dietary ethanol on ascorbic acid and lipid metabolism, and liver drug-metabolizing enzymes in rats fed a semi-purified diet containing a powdered ethanol preparation (30 cal% in the diet) were studied. Administration of ethanol increased urinary ascorbic acid excretion (p less than 0.001) and ascorbic acid level in the liver (p less than 0.001) and the spleen (p less than 0.01). The activity of hepatic aniline hydroxylase was increased (p less than 0.05) by ethanol feeding but that of aminopyrine N-demethylase was not. Increases of serum total and high-density-lipoprotein (HDL) cholesterol level, commonly observed by the administration of xenobiotics, were not observed. These results showed ethanol possessed rather similar properties to xenobiotics such as polychlorinated biphenyls (PCB) or 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (DDT) in some metabolic changes. In this study, no accumulation of lipid in the liver was observed.
研究了膳食乙醇对喂食含粉状乙醇制剂（占饮食热量的30%）的半纯化饮食的大鼠中抗坏血酸和脂质代谢以及肝脏药物代谢酶的影响。给予乙醇会增加尿中抗坏血酸排泄量（p<0.001）、肝脏中抗坏血酸水平（p<0.001）以及脾脏中抗坏血酸水平（p<0.01）。喂食乙醇会增加肝脏苯胺羟化酶的活性（p<0.05），但氨基比林N-脱甲基酶的活性未增加。未观察到通常通过给予外源化合物而观察到的血清总胆固醇和高密度脂蛋白（HDL）胆固醇水平的升高。这些结果表明，乙醇在某些代谢变化中具有与多氯联苯（PCB）或1,1,1-三氯-2,2-双（对氯苯基）乙烷（DDT）等外源化合物相当相似的特性。在本研究中，未观察到肝脏中脂质的积累。
