Pauletto P, Scannapieco G, Vescovo G, Pessina A C, Dal Palù C
Clinica Medica I, University of Padua, Italy.
J Hypertens Suppl. 1989 Dec;7(6):S246-7. doi: 10.1097/00004872-198900076-00119.
In spontaneously hypertensive turkeys, both high blood pressure and high catecholamine levels play a role in the development of vascular hypertrophy. We studied the effect of labetalol, an alpha- and beta-blocking drug, on the aortic media. Seventeen turkeys were given increasing doses of the drug (20-35 mg/kg daily) from the 2nd to the 35th week of age; 13 control birds were given a daily placebo. The actively treated turkeys showed significantly lower values of blood pressure and a lower heart rate compared with the controls throughout the study period. After the turkeys had been killed, seriate histological sections taken from the abdominal aorta near the bifurcation were used for a three-dimensional assessment of the aortic media by computerized morphometry. The volume of aortic media was significantly lower in the labetalol-treated birds than in the controls. This was also observed in the non-responder turkeys. This finding indirectly supports the view that catecholamines may play a major but independent role in the development of vascular hypertrophy.
在自发性高血压火鸡中，高血压和高儿茶酚胺水平均在血管肥厚的发展过程中起作用。我们研究了α和β受体阻滞剂拉贝洛尔对主动脉中膜的影响。17只火鸡从2周龄至35周龄给予递增剂量的该药（每日20 - 35mg/kg）；13只对照火鸡给予每日安慰剂。在整个研究期间，积极治疗的火鸡与对照组相比，血压值显著降低，心率也较低。火鸡处死后，从分叉附近的腹主动脉获取的系列组织学切片用于通过计算机形态测量法对主动脉中膜进行三维评估。拉贝洛尔治疗组火鸡的主动脉中膜体积显著低于对照组。在无反应的火鸡中也观察到了这一点。这一发现间接支持了儿茶酚胺可能在血管肥厚的发展中起主要但独立作用的观点。
