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生物活性玻璃用于兔腔洞性骨缺损：一项对比实验研究

Bioactive glass in cavitary bone defects: a comparative experimental study in rabbits.

作者信息

Camargo André Ferrari de França, Baptista André Mathias, Natalino Renato, de Camargo Olavo Pires

机构信息

Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina, Instituto de Ortopedia e Traumatologia do, São Paulo, SP, Brazil.

Universidade de São Paulo, Faculdade de Medicina, Department of Orthopedics and Traumatology, São Paulo, SP, Brazil.

出版信息

Acta Ortop Bras. 2015 Jul-Aug;23(4):202-7. doi: 10.1590/1413-785220152304147538.

DOI:10.1590/1413-785220152304147538
PMID:26327802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4544529/
Abstract

OBJECTIVES

To compare bioactive glass and autograft regarding their histomorphometric characteristics.

METHODS

The authors conducted a prospective case-control experimental study on animals in order to compare the histomorphometric characteristics of bioactive glass versus autograft. Eight rabbits underwent surgery in which a cavitary defect was created in both proximal femurs. One side was filled with bioactive glass granules and the other, with autograft grafted from the contralateral side. The sides were randomized. Fourteen days after surgery, the animals were euthanized.

RESULTS

Histologic analysis revealed that bone neoformation was equivalent among the two groups and the osteoblasts cell-count was higher in the femurs treated with bioactive glass. The osteocytes cell-count, however, was lower. The similarity in bone formation between both groups was consistent to literature findings.

CONCLUSION

Bioactive glass is similar to autograft regarding bone neoformation in this animal model of cavitary bone defects. Level of Evidence III, Case-Control Study.

摘要

目的

比较生物活性玻璃和自体骨移植在组织形态计量学特征方面的差异。

方法

作者对动物进行了一项前瞻性病例对照实验研究，以比较生物活性玻璃与自体骨移植的组织形态计量学特征。8只兔子接受手术，在双侧股骨近端制造腔隙性缺损。一侧填充生物活性玻璃颗粒，另一侧填充从对侧移植的自体骨。两侧随机分配。术后14天，对动物实施安乐死。

结果

组织学分析显示，两组的骨新形成情况相当，在用生物活性玻璃治疗的股骨中，成骨细胞计数较高。然而，骨细胞计数较低。两组之间骨形成的相似性与文献研究结果一致。

结论

在这种腔隙性骨缺损动物模型中，生物活性玻璃在骨新形成方面与自体骨移植相似。证据级别III，病例对照研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/bb68efd72685/1413-7852-aob-23-04-00202-gf10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/f2749c276e93/1413-7852-aob-23-04-00202-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/127a72a51b59/1413-7852-aob-23-04-00202-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/0a7b9e54c39b/1413-7852-aob-23-04-00202-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/28c0b485daa6/1413-7852-aob-23-04-00202-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/1abb14a1e87d/1413-7852-aob-23-04-00202-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/1e13f01a66db/1413-7852-aob-23-04-00202-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/174ede8ee5c4/1413-7852-aob-23-04-00202-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/e90d9cc1b0ba/1413-7852-aob-23-04-00202-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/10fc83840bb3/1413-7852-aob-23-04-00202-gf09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/bb68efd72685/1413-7852-aob-23-04-00202-gf10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/f2749c276e93/1413-7852-aob-23-04-00202-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/127a72a51b59/1413-7852-aob-23-04-00202-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/0a7b9e54c39b/1413-7852-aob-23-04-00202-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/28c0b485daa6/1413-7852-aob-23-04-00202-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/1abb14a1e87d/1413-7852-aob-23-04-00202-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/1e13f01a66db/1413-7852-aob-23-04-00202-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/174ede8ee5c4/1413-7852-aob-23-04-00202-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/e90d9cc1b0ba/1413-7852-aob-23-04-00202-gf08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/10fc83840bb3/1413-7852-aob-23-04-00202-gf09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/892f/4544529/bb68efd72685/1413-7852-aob-23-04-00202-gf10.jpg

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