Godala Małgorzata, Materek-Kuśmierkiewicz Izabela, Moczulski Dariusz, Gaszyńska Ewelina, Szatko Franciszek, Tokarski Sławomir, Kowalski Jan
Department of Nutrition and Epidemiology, Chair of Hygiene and Epidemiology, Medical University of Lodz, Poland.
Department of Internal Medicine and Nephrodiabetology, Chair of Internal Diseases and Cardiology, Medical University of Lodz, Poland.
Prz Menopauzalny. 2014 Oct;13(5):293-7. doi: 10.5114/pm.2014.46473. Epub 2014 Nov 2.
Vitamin D deficiency is a risk factor for metabolic syndrome disorders and the occurrence of these disorders greatly contributes to the deficiency of vitamin D. Postmenopausal women are particularly prone to that deficiency.
The aim of the study was to assess vitamin D concentration in the plasma of pre- and postmenopausal women, with or without metabolic syndrome.
The study included 141 women aged 26-77 (the mean age 58.74 years old), divided into 4 groups depending on the pre- or postmenopausal period and diagnosed or not with metabolic syndrome according to the International Diabetes Federation criteria (2005). Vitamin D concentration was assessed by LIAISON(®) test using chemiluminescent immunoassay (CLIA) technology.
The mean vitamin D concentration was the highest among premenopausal women without metabolic syndrome (24.32 ng/ml), it was insignificantly higher than in postmenopausal women without metabolic syndrome (23.52 ng/ml) and significantly higher than in both groups with metabolic syndrome - premenopausal (19.86 ng/ml) and postmenopausal women (9.32 ng/ml). The recommended plasma 25(OH)D concentration was not found in any of postmenopausal women with diagnosed metabolic syndrome.
Postmenopausal women with metabolic syndrome had a significantly lower 25(OH)D vitamin concentration in plasma than postmenopausal women without metabolic syndrome. The frequency of vitamin D deficiency in women with metabolic syndrome was very high, significantly higher than in women without metabolic syndrome.
维生素D缺乏是代谢综合征紊乱的一个风险因素，而这些紊乱的发生极大地导致了维生素D的缺乏。绝经后女性尤其容易出现这种缺乏。
本研究的目的是评估有或无代谢综合征的绝经前和绝经后女性血浆中的维生素D浓度。
该研究纳入了141名年龄在26 - 77岁（平均年龄58.74岁）的女性，根据绝经前或绝经后时期以及是否根据国际糖尿病联盟标准（2005年）诊断为代谢综合征分为4组。使用化学发光免疫分析（CLIA）技术通过LIAISON（®）检测评估维生素D浓度。
在无代谢综合征的绝经前女性中，平均维生素D浓度最高（24.32 ng/ml），略高于无代谢综合征的绝经后女性（23.52 ng/ml），且显著高于两组有代谢综合征的女性——绝经前（19.86 ng/ml）和绝经后女性（9.32 ng/ml）。在任何诊断为代谢综合征的绝经后女性中均未发现推荐的血浆25(OH)D浓度。
患有代谢综合征的绝经后女性血浆中25(OH)D维生素浓度显著低于无代谢综合征的绝经后女性。患有代谢综合征的女性维生素D缺乏的频率非常高，显著高于无代谢综合征的女性。
