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Stone growth patterns and risk for surgery among children presenting with hypercalciuria, hypocitraturia and cystinuria as underlying metabolic causes of urolithiasis.以高钙尿症、低枸橼酸尿症和胱氨酸尿症作为潜在代谢病因的儿童肾结石患者的结石生长模式及手术风险。
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The global, regional, and national burden of pediatric stone disease: 1990-2021 and projections for the next two decades.儿童结石病的全球、区域和国家负担:1990 - 2021年及未来二十年预测
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Association between dietary pattern and metabolic disorders in children and adolescents with urolithiasis.饮食模式与尿路结石患儿和青少年代谢紊乱的关系。
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本文引用的文献

1
Urolithiasis in children: medical approach.儿童尿路结石:医学处理方法。
Pediatr Clin North Am. 2012 Aug;59(4):881-96. doi: 10.1016/j.pcl.2012.05.009. Epub 2012 Jun 15.
2
Reduction of plasma oxalate levels by oral application of Oxalobacter formigenes in 2 patients with infantile oxalosis.口服产甲酸草酸杆菌降低 2 例婴儿型草酸钙沉着症患者血浆草酸盐水平。
Am J Kidney Dis. 2011 Sep;58(3):453-5. doi: 10.1053/j.ajkd.2011.05.012. Epub 2011 Jun 25.
3
Mutations in DHDPSL are responsible for primary hyperoxaluria type III.DHDPSL 基因突变是引起 III 型原发性高草酸尿症的原因。
Am J Hum Genet. 2010 Sep 10;87(3):392-9. doi: 10.1016/j.ajhg.2010.07.023.
4
Claudin-16 and claudin-19 function in the thick ascending limb.Claudin-16 和 Claudin-19 在厚升支中起作用。
Curr Opin Nephrol Hypertens. 2010 Sep;19(5):483-8. doi: 10.1097/MNH.0b013e32833b7125.
5
Effects of a low-salt diet on idiopathic hypercalciuria in calcium-oxalate stone formers: a 3-mo randomized controlled trial.低钠饮食对草酸钙结石形成者特发性高钙尿症的影响:一项 3 个月随机对照试验。
Am J Clin Nutr. 2010 Mar;91(3):565-70. doi: 10.3945/ajcn.2009.28614. Epub 2009 Dec 30.
6
Late diagnosis of primary hyperoxaluria after failed kidney transplantation.原发性高草酸尿症在肾移植失败后被漏诊。
Int Urol Nephrol. 2010 Sep;42(3):825-9. doi: 10.1007/s11255-009-9690-2. Epub 2009 Dec 18.
7
Pediatric urolithiasis.小儿尿路结石症
Curr Opin Urol. 2009 Jul;19(4):419-23. doi: 10.1097/MOU.0b013e32832c9096.
8
Urine calcium/citrate ratio in children with hypercalciuric stones.高钙尿性结石患儿的尿钙/枸橼酸盐比值
Pediatr Res. 2009 Jul;66(1):85-90. doi: 10.1203/PDR.0b013e3181a2939e.
9
The primary hyperoxalurias.原发性高草酸尿症
Kidney Int. 2009 Jun;75(12):1264-1271. doi: 10.1038/ki.2009.32. Epub 2009 Feb 18.
10
Role of overweight and obesity on the urinary excretion of promoters and inhibitors of stone formation in stone formers.超重和肥胖对结石形成者尿液中结石形成促进剂和抑制剂排泄的作用。
Urol Res. 2008 Dec;36(6):303-7. doi: 10.1007/s00240-008-0161-5. Epub 2008 Nov 5.

小儿尿路结石的当前医学治疗方法。

Current medical treatment in pediatric urolithiasis.

作者信息

Akın Yiğit, Uçar Murat, Yücel Selçuk

机构信息

Department of Urology, Faculty of Medicine, Erzincan University, Erzincan, Turkey.

Department of Urology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

出版信息

Turk J Urol. 2013 Dec;39(4):253-63. doi: 10.5152/tud.2013.063.

DOI:10.5152/tud.2013.063
PMID:26328120
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4548612/
Abstract

Although the prevalence of urolithiasis is nearly 2-3% in childhood, the risk of recurrence may range from 6.5-54%. There has been an increase in urinary stone disease among pediatric age groups, and stone disease has a multifactorial etiology. After the diagnosis, detailed metabolic evaluation is required. High recurrence rates, therapeutic irregularities and deficiency in diagnosis may lead to comorbidities such as loss of kidney function. Following diagnosis, the requirement for surgery, such as stone extraction and correction of anatomical anomalies, is determined. Medical and supportive treatments are also needed to prevent recurrence and urinary tract infections and to preserve renal function. Supportive care includes increased fluid intake and dietary modifications. Medical treatment is dependent on the cause of the urinary stone disease. The morbidities associated with pediatric urolithiasis can be prevented by early diagnosis, detailed metabolic analysis, regular follow-up and medical treatment protocols.

摘要

尽管儿童期尿石症的患病率接近2%-3%,但其复发风险可能在6.5%-54%之间。小儿年龄段的尿路结石病有所增加,且结石病病因是多因素的。诊断后,需要进行详细的代谢评估。高复发率、治疗不规范及诊断不足可能导致诸如肾功能丧失等合并症。诊断后,确定是否需要进行手术,如取石及纠正解剖异常。还需要药物和支持性治疗以预防复发和尿路感染并保护肾功能。支持性护理包括增加液体摄入量和调整饮食。药物治疗取决于尿路结石病的病因。通过早期诊断、详细的代谢分析、定期随访和药物治疗方案,可以预防与小儿尿石症相关的发病情况。