Mandeville Jessica A, Nelson Caleb P
Children's Hospital Boston, Boston, Massachusetts 02468, USA.
Curr Opin Urol. 2009 Jul;19(4):419-23. doi: 10.1097/MOU.0b013e32832c9096.
We review the recent literature on pediatric urolithiasis and present up-to-date findings on epidemiology, diagnosis, and medical and surgical management.
There are surprisingly few reliable data on pediatric urolithiasis incidence, but widespread anecdotal and single-center reports suggest that more children with stones are being seen. The contamination of Chinese infant formula with melamine caused urolithiasis and other renal problems in hundreds of thousands of infants in the region, underlining the role of environmental factors in urolithiasis. Efforts continue to determine normal metabolic parameters in children, but have been hampered by variations among regions, races, and ethnicities. The Bonn Risk Index may prove to be a useful tool for assessing risk of urolithiasis in children. Children with recurrent urolithiasis are more likely to have detectable metabolic abnormalities. Surgical approaches to urolithiasis in children continue to evolve, with robotic-assisted laparoscopy being perhaps the most significant new technique. Finally, clinicians and radiologists must be aware of the potential for dextranomer/hyaluronic acid (Deflux) implants to mimic distal ureteral stones on computed tomography (CT) scan.
Pediatric urolithiasis is an expanding field, due in part to the apparent increase in cases. Research continues, seeking to refine the appropriate diagnostic and therapeutic approaches in these unfortunate children.
我们回顾了近期关于小儿尿石症的文献,并介绍了有关流行病学、诊断以及药物和手术治疗的最新研究结果。
令人惊讶的是,关于小儿尿石症发病率的可靠数据很少,但广泛的传闻和单中心报告表明,患结石的儿童越来越多。中国婴幼儿配方奶粉被三聚氰胺污染,导致该地区数十万婴儿患上尿石症及其他肾脏问题,凸显了环境因素在尿石症中的作用。确定儿童正常代谢参数的工作仍在继续,但受到地区、种族和民族差异的阻碍。波恩风险指数可能被证明是评估儿童尿石症风险的有用工具。复发性尿石症患儿更有可能存在可检测到的代谢异常。小儿尿石症的手术方法不断发展,机器人辅助腹腔镜手术可能是最重要的新技术。最后,临床医生和放射科医生必须意识到,葡聚糖凝胶/透明质酸(Deflux)植入物在计算机断层扫描(CT)上可能会被误诊为远端输尿管结石。
小儿尿石症是一个不断发展的领域,部分原因是病例数明显增加。研究仍在继续,旨在完善针对这些不幸儿童的适当诊断和治疗方法。