接受根治性前列腺切除术的低风险前列腺癌患者生化复发的决定因素。
Factors determining biochemical recurrence in low-risk prostate cancer patients who underwent radical prostatectomy.
作者信息
Ün Sıtkı, Türk Hakan, Koca Osman, Divrik Rauf Taner, Zorlu Ferruh
机构信息
Clinic of Urology, Tepecik Training and Research Hospital, İzmir, Turkey.
出版信息
Turk J Urol. 2015 Jun;41(2):61-6. doi: 10.5152/tud.2015.65624.
OBJECTIVE
This study was conducted to research the factors determining biochemical recurrence (BCR) in low-risk localized prostate cancer patients who underwent radical prostatectomy (RP).
MATERIALS AND METHODS
We retrospectively analyzed the data of 504 patients who had undergone RP between 2003 and 2013 at our clinic. One hundred and fifty-two patients who underwent RP for low-risk prostate cancer were included in the study.
RESULTS
The mean follow-up period for patients was 58.7 (21-229) months. The mean age of the patients was 63.7±7.2 years (49-79). The mean prostate specific antigen (PSA) value was 5.25±4.22 ng/mL (3.58-9.45). The BCR rate after the operation was 25% (38/152). In the univariate analysis, recurrence determining factors were shown to include extracapsular involvement (ECI) (p=0.004), capsular invasion (CI) (p=0.001), age (p=0.014), and tumor size (p=0.006). However, only CI was found to be significant in multivariate analysis (p=0.001).
CONCLUSION
Capsular invasion is an independent risk factor in low-risk prostate cancer patients who underwent RP for BCR.
目的
本研究旨在探究接受根治性前列腺切除术（RP）的低风险局限性前列腺癌患者发生生化复发（BCR）的决定因素。
材料与方法
我们回顾性分析了2003年至2013年间在我院接受RP治疗的504例患者的数据。本研究纳入了152例因低风险前列腺癌接受RP治疗的患者。
结果
患者的平均随访期为58.7（21 - 229）个月。患者的平均年龄为63.7±7.2岁（49 - 79岁）。平均前列腺特异性抗原（PSA）值为5.25±4.22 ng/mL（3.58 - 9.45）。术后BCR率为25%（38/152）。在单因素分析中，复发决定因素包括包膜外侵犯（ECI）（p = 0.004）、包膜侵犯（CI）（p = 0.001）、年龄（p = 0.014）和肿瘤大小（p = 0.006）。然而，在多因素分析中仅发现CI具有显著性（p = 0.001）。
结论
对于接受RP治疗的低风险前列腺癌患者，包膜侵犯是BCR的独立危险因素。
Zotero 插件