Odai Tsuyoshi, Isozaki Takeo, Kasama Tsuyoshi, Ogata Hiroaki, Kinugasa Eriko
Division of General Internal Medicine, Ebina General Hospital, Japan.
Intern Med. 2015;54(17):2261-6. doi: 10.2169/internalmedicine.54.4271. Epub 2015 Sep 1.
This is the first report of the efficacy of leukocytapheresis (LCAP) in a patient with refractory adult onset Still's disease (AOSD) during pregnancy. A 32-year-old Chinese pregnant woman with AOSD who had been treated with prednisolone failed to achieve disease stabilization. The patient's disease was successfully controlled with the initiation of LCAP. Subsequently, she gave birth via Caesarean section to a 1,878 g baby boy at 34 weeks of gestation while maintaining remission. We conclude that LCAP is an alternative treatment in pregnant patients with refractory AOSD, particularly in those concerned about potential teratogenic and other adverse effects.
这是关于白细胞去除术（LCAP）对一名妊娠期间难治性成人斯蒂尔病（AOSD）患者疗效的首例报告。一名32岁患有AOSD的中国孕妇，曾接受泼尼松龙治疗，但病情未能稳定。患者的病情通过启动LCAP成功得到控制。随后，她在妊娠34周时通过剖宫产分娩出一名体重1878克的男婴，同时病情保持缓解。我们得出结论，LCAP是妊娠期间难治性AOSD患者的一种替代治疗方法，特别是对于那些担心潜在致畸和其他不良反应的患者。
