氧感知与稳态
Oxygen Sensing and Homeostasis.
作者信息
Prabhakar Nanduri R, Semenza Gregg L
机构信息
Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois;
Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland; and McKusick-Nathans Institute of Genetic Medicine and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland.
出版信息
Physiology (Bethesda). 2015 Sep;30(5):340-8. doi: 10.1152/physiol.00022.2015.
Abstract
The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.
摘要
颈动脉体作为检测动脉血氧水平的感觉受体的发现，以及缺氧诱导因子（HIFs）在氧稳态中的作用的鉴定和阐明，推动了氧生物学领域的发展。本综述重点介绍了与氧感知相关的气体信使信号传导机制，以及HIFs维持氧稳态的转录和非转录机制及其与生理和病理的相关性。
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