Guan Lijuan, Rizzello Loris, Battaglia Giuseppe
Department of Chemistry, University College London, London, WC1H 0AJ, UK.
MRC Center for Medical Molecular Virology, University College London, London, WC1H 0AJ, UK.
Nanomedicine (Lond). 2015;10(17):2757-80. doi: 10.2217/nnm.15.110. Epub 2015 Sep 2.
Polymersomes have been proposed as a platform for drug delivery systems since late 90s. They are exploited to deliver hydrophilic and/or hydrophobic therapeutic and diagnostic agents. The relatively robust membrane, the colloidal stability, along with a significant biocompatibility and easy ligands conjugation methods make polymersomes primary candidates for therapeutic drugs delivery in cancer clinical treatments. In addition, they represent an optimal choice as imaging tools in noninvasive diagnostic. As a result, polymersomes have been proposed and widely studied for anticancer treatments. However, there are not sufficient clinic translation data of human studies yet. In this critical review, we will discuss such topics, focusing on the self-assembly of membrane-forming copolymers, on their tunable physicochemical properties and on the consequential applications of these biocompatible polymersomes in drug delivery and cancer therapy.
自20世纪90年代末以来，聚合物囊泡就被提议作为药物递送系统的一个平台。它们被用于递送亲水性和/或疏水性治疗和诊断剂。相对坚固的膜、胶体稳定性，以及显著的生物相容性和简便的配体偶联方法，使聚合物囊泡成为癌症临床治疗中治疗药物递送的主要候选者。此外，它们作为非侵入性诊断中的成像工具是一个最佳选择。因此，聚合物囊泡已被提议并广泛用于抗癌治疗研究。然而，目前还没有足够的人体临床转化数据。在这篇批判性综述中，我们将讨论这些主题，重点关注成膜共聚物的自组装、它们可调节的物理化学性质，以及这些生物相容性聚合物囊泡在药物递送和癌症治疗中的相应应用。
