用于药物递送的纳米级聚合物囊泡作为抗癌药物载体
Nanoscale Polymersomes as Anti-Cancer Drug Carriers Applied for Pharmaceutical Delivery.
作者信息
Tuguntaev Ruslan G, Okeke Chukwunweike Ikechukwu, Xu Jing, Li Chan, Wang Paul C, Liang Xing-Jie
机构信息
Laboratory of Controllable Nanopharmaceuticals, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
出版信息
Curr Pharm Des. 2016;22(19):2857-65. doi: 10.2174/1381612822666160217142319.
Abstract
Polymersomes are self-assembled nano-vesicles composed of amphiphilic block copolymers. These building blocks can be selected from a large number of hydrophilic and hydrophobic polymers in order to achieve required properties of the final system, such as biodegradability, sustainable and multiple stimuli-response drug release, long blood circulation, and low toxicity. Moreover, the surface of polymersomes can be functionalized to induce targeting character. Polymersomes are able to encapsulate a broad range of hydrophilic or/and hydrophobic molecules either in the aqueous core or membrane bilayer, respectively. In addition, colloidal stability and low membrane fluidity make polymersomes attractive nano-sized drug carriers. The review describes polymersomes compositions, their applications in pharmaceutical delivery, and preparation methods.
摘要
聚合物囊泡是由两亲性嵌段共聚物自组装而成的纳米囊泡。这些构建块可以从大量的亲水和疏水聚合物中选择，以实现最终体系所需的性质，如生物可降解性、可持续和多重刺激响应药物释放、长循环时间和低毒性。此外，聚合物囊泡的表面可以进行功能化修饰以引入靶向特性。聚合物囊泡能够分别在水相核心或膜双分子层中包裹多种亲水或/和亲脂性分子。此外，胶体稳定性和低膜流动性使聚合物囊泡成为有吸引力的纳米级药物载体。本文综述了聚合物囊泡的组成、其在药物递送中的应用以及制备方法。
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