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[经颅电刺激阿片系统对心肌梗死患者修复过程的影响]

[Effects of transcranial electrostimulation of the opioid systems on reparative processes in patients with myocardial infarct].

作者信息

Golikov A P, Pavlov V A, Karev V A, Polumiskov V Iu, Lebedev V P, Katsnel'son Ia S, Trofimov A K, Il'inskiĭ O B

出版信息

Kardiologiia. 1989 Dec;29(12):45-8.

PMID:2632925
Abstract

Sixty three patients with primary excessive myocardial infarction (MI) were examined. Transcranial electric stimulation (TES) was demonstrated to contribute to more rapid formation of a postinfarction scar, development of compensatory hypertrophy of the preserved myocardium, and improvement of cardiac contractility. TES-induced activation of the endogenous opioid system was found to be one of the mechanisms responsible for stimulation of reparative processes in patients with MI. Introduction of TES into the multimodality therapy for MI improves the clinical picture of the disease, promoting diminution of circulatory failure signs and relapses of angina-associated pains and favoring decrease in the long-term course of MI and frequency of cardiac arrhythmias.

摘要

对63例原发性心肌梗死(MI)患者进行了检查。经颅电刺激(TES)被证明有助于梗死灶后瘢痕的更快形成、保留心肌的代偿性肥大的发展以及心脏收缩力的改善。发现TES诱导的内源性阿片系统激活是刺激MI患者修复过程的机制之一。将TES引入MI的多模式治疗可改善疾病的临床表现,促进循环衰竭体征和心绞痛相关疼痛复发的减轻,并有利于MI长期病程和心律失常频率的降低。

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