Shariff Khairul Anuar, Tsuru Kanji, Ishikawa Kunio
Faculty of Dental Science, Department of Biomaterials, Kyushu University, Fukuoka, Japan.
Faculty of Dental Science, Department of Biomaterials, Kyushu University, Fukuoka, Japan
J Biomater Appl. 2016 Jan;30(6):838-45. doi: 10.1177/0885328215601939. Epub 2015 Sep 1.
Interconnected pore forming calcium phosphate cement is useful for the reconstruction of bone defects as well as scaffold fabrication in tissue engineering. In this study, interconnected pore forming calcium phosphate cement was fabricated using α-tricalcium phosphate (α-TCP) foam granules. When α-TCP foam granules were mixed with acidic calcium phosphate solution prepared from monocalcium phosphate monohydrate (MCPM) and phosphoric acid solution, brushite crystals were precipitated. These crystals bridged the α-TCP foam granules immediately upon mixing. As a result of the brushite bridge between the α-TCP foam granules, fully interconnected macroporous α-TCP was obtained. The amount of brushite precipitate and the mechanical strength of the set cement increased with acidic calcium phosphate concentration.
相互连通的成孔磷酸钙骨水泥可用于骨缺损修复以及组织工程中的支架制造。在本研究中，使用α-磷酸三钙（α-TCP）泡沫颗粒制备了相互连通的成孔磷酸钙骨水泥。当α-TCP泡沫颗粒与由一水磷酸二氢钙（MCPM）和磷酸溶液制备的酸性磷酸钙溶液混合时，会析出透钙磷石晶体。这些晶体在混合后立即桥接α-TCP泡沫颗粒。由于α-TCP泡沫颗粒之间形成了透钙磷石桥，从而获得了完全相互连通的大孔α-TCP。透钙磷石沉淀量和固化骨水泥的机械强度随酸性磷酸钙浓度的增加而提高。
