通过对分子羧基末端区域具有主要特异性的放射免疫测定法评估甲状旁腺激素分泌的急性和慢性变化。

Assessment of acute and chronic changes in parathyroid hormone secretion by a radioimmunoassay with predominant specificity for the carboxy-terminal region of the molecule.

作者信息

Parthemore J G, Roos B A, Parker D C, Kripke D F, Avioli L V, Deftos L J

出版信息

J Clin Endocrinol Metab. 1978 Aug;47(2):284-9. doi: 10.1210/jcem-47-2-284.

Abstract

A sensitive RIA for parathyroid hormone (PTH) with specificity for the carboxy-terminal region of the hormone was developed and applied to clinical studies. The assay was useful in identifying patients with chronic hyperparathyroid states, such as primary and secondary hyperparathyroidism. In addition, the assay could detect acute changes in PTH seen during calcium, pentagastrin, and EDTA infusions and after parathyroidectomy. These studies demonstrated that an immunoassay with predominant specificity for the carboxy-terminal fragment of PTH can be used to evaluate acute as well as chronic changes in hormone secretion.

摘要

开发了一种对甲状旁腺激素（PTH）具有特异性、针对该激素羧基末端区域的灵敏放射免疫分析方法，并将其应用于临床研究。该分析方法有助于识别患有慢性甲状旁腺功能亢进状态的患者，如原发性和继发性甲状旁腺功能亢进。此外，该分析方法能够检测在输注钙、五肽胃泌素和乙二胺四乙酸（EDTA）期间以及甲状旁腺切除术后所观察到的PTH的急性变化。这些研究表明，一种对PTH羧基末端片段具有主要特异性的免疫分析方法可用于评估激素分泌的急性和慢性变化。