Deftos L J, Parthemore J G
J Clin Invest. 1974 Aug;54(2):416-20. doi: 10.1172/JCI107777.
The secretion of parathyroid hormone (PTH) and calcitonin (CT) was studied in 30 patients with medullary thyroid carcinoma. Most patients with elevated levels of CT were normocalcemic and also had normal basal levels of PTH. Five of six patients with associated hyperparathyroidism were hypercalcemic and had elevated basal PTH levels. Hormone secretion was also studied during infusions with standard and low doses of calcium. PTH unexpectedly increased during 12 of 18 calcium infusions. Such a paradoxical increase in PTH was seen in those patients with the greatest increase in CT and the least increase in calcium during the calcium infusion. Accordingly, increases in PTH concentration during the calcium infusions could be correlated directly with increases in CT and correlated inversely with increases in calcium. These observations suggest that, in some patients with medullary thyroid carcinoma, a further increase in the abnormally elevated CT levels may stimulate PTH secretion. Therefore, at least in acute studies, there may be a functional, as well as a genetic, relationship between the secretion of these two hormones in patients with this thyroid tumor.
对30例甲状腺髓样癌患者的甲状旁腺激素（PTH）和降钙素（CT）分泌情况进行了研究。大多数CT水平升高的患者血钙正常，且PTH基础水平也正常。6例伴有甲状旁腺功能亢进的患者中有5例血钙升高，且PTH基础水平升高。还在输注标准剂量和低剂量钙的过程中研究了激素分泌情况。在18次钙输注中有12次PTH意外升高。在钙输注过程中CT升高幅度最大且钙升高幅度最小的患者中出现了这种PTH的反常升高。因此，钙输注过程中PTH浓度的升高与CT的升高直接相关，与钙的升高呈负相关。这些观察结果表明，在一些甲状腺髓样癌患者中，异常升高的CT水平进一步升高可能会刺激PTH分泌。因此，至少在急性研究中，这种甲状腺肿瘤患者的这两种激素分泌之间可能存在功能以及遗传上的关系。
