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Argon: a novel therapeutic option to treat neuronal ischemia and reperfusion injuries?氩气：治疗神经元缺血和再灌注损伤的一种新的治疗选择？
Neural Regen Res. 2015 Jul;10(7):1043-4. doi: 10.4103/1673-5374.160071.
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Neuroprotective effects of Argon are mediated via an ERK-1/2 dependent regulation of heme-oxygenase-1 in retinal ganglion cells.氩气的神经保护作用是通过视网膜神经节细胞中血红素加氧酶-1的ERK-1/2依赖性调节介导的。
J Neurochem. 2015 Aug;134(4):717-27. doi: 10.1111/jnc.13115. Epub 2015 Apr 27.
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Argon inhalation attenuates retinal apoptosis after ischemia/reperfusion injury in a time- and dose-dependent manner in rats.氩气吸入以时间和剂量依赖性方式减轻大鼠缺血/再灌注损伤后的视网膜细胞凋亡。
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Argon mediates protection by interleukin-8 suppression via a TLR2/TLR4/STAT3/NF-κB pathway in a model of apoptosis in neuroblastoma cells in vitro and following ischemia-reperfusion injury in rat retina in vivo.在体外神经母细胞瘤细胞凋亡模型以及体内大鼠视网膜缺血再灌注损伤模型中，氩气通过TLR2/TLR4/STAT3/NF-κB途径抑制白细胞介素-8来介导保护作用。
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Susceptibility of hippocampal and cortical neurons to argon-mediated in vitro ischemia.海马体和皮质神经元对氩气介导的体外缺血的易感性。
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Pretreatment With Argon Protects Human Cardiac Myocyte-Like Progenitor Cells from Oxygen Glucose Deprivation-Induced Cell Death by Activation of AKT and Differential Regulation of Mapkinases.预处理氩气通过激活 AKT 和差异调节丝裂原活化蛋白激酶来保护人心肌细胞样祖细胞免于氧葡萄糖剥夺诱导的细胞死亡。
Shock. 2018 May;49(5):556-563. doi: 10.1097/SHK.0000000000000998.
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[Limb ischemic preconditioning decreases hippocampal ischemia/reperfusion injuries in rats].
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2004 Feb;20(1):50-3.

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Neuroprotection Is in the Air-Inhaled Gases on Their Way to the Neurons.神经保护无处不在——吸入气体通往神经元的路上。
Cells. 2023 Oct 18;12(20):2480. doi: 10.3390/cells12202480.
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A New Discovery of Argon Functioning in Plants: Regulation of Salinity Tolerance.氩在植物中的新发现：耐盐性调控
Antioxidants (Basel). 2022 Jun 14;11(6):1168. doi: 10.3390/antiox11061168.
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A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice.一种用于治疗小鼠急性一氧化碳中毒的新型有效化学血红素。
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A porcine lung perfusion model with maximal argon exposure to attenuate ischemia-reperfusion injury.一种用于最大程度暴露于氩气以减轻缺血再灌注损伤的猪肺灌注模型。
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Argon does not affect cerebral circulation or metabolism in male humans.氩气对男性人体的脑循环和代谢没有影响。
PLoS One. 2017 Feb 16;12(2):e0171962. doi: 10.1371/journal.pone.0171962. eCollection 2017.
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The Molecular Pathway of Argon-Mediated Neuroprotection.氩气介导神经保护的分子途径
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Argon Induces Protective Effects in Cardiomyocytes during the Second Window of Preconditioning.氩气在预处理的第二窗口期对心肌细胞产生保护作用。
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本文引用的文献

1
Argon inhalation attenuates retinal apoptosis after ischemia/reperfusion injury in a time- and dose-dependent manner in rats.氩气吸入以时间和剂量依赖性方式减轻大鼠缺血/再灌注损伤后的视网膜细胞凋亡。
PLoS One. 2014 Dec 23;9(12):e115984. doi: 10.1371/journal.pone.0115984. eCollection 2014.
2
Dose dependent neuroprotection of the noble gas argon after cardiac arrest in rats is not mediated by K(ATP)-channel opening.在大鼠心脏骤停后，惰性气体氩的剂量依赖性神经保护作用不是通过 K(ATP)通道开放介导的。
Resuscitation. 2014 Jun;85(6):826-32. doi: 10.1016/j.resuscitation.2014.02.014. Epub 2014 Feb 28.
3
Postresuscitation treatment with argon improves early neurological recovery in a porcine model of cardiac arrest.氩气复苏后治疗可改善猪心搏骤停模型的早期神经功能恢复。
Shock. 2014 Jan;41(1):72-8. doi: 10.1097/SHK.0000000000000049.
4
Argon reduces neurohistopathological damage and preserves functional recovery after cardiac arrest in rats.氩气可减轻心跳骤停后大鼠的神经组织病理损伤，并保护其功能恢复。
Br J Anaesth. 2013 Jun;110 Suppl 1:i106-12. doi: 10.1093/bja/aes509. Epub 2013 Feb 7.
5
Ex vivo and in vivo neuroprotection induced by argon when given after an excitotoxic or ischemic insult.兴奋性毒性或缺血性损伤后给予氩气诱导的离体和体内神经保护作用。
PLoS One. 2012;7(2):e30934. doi: 10.1371/journal.pone.0030934. Epub 2012 Feb 22.
6
The noble gas argon modifies extracellular signal-regulated kinase 1/2 signaling in neurons and glial cells.稀有气体氩可调节神经元和神经胶质细胞细胞外信号调节激酶 1/2 的信号转导。
Eur J Pharmacol. 2012 Jan 15;674(2-3):104-11. doi: 10.1016/j.ejphar.2011.10.045. Epub 2011 Nov 7.
7
Neuroprotective effects of argon in an in vivo model of transient middle cerebral artery occlusion in rats.氩气对大鼠短暂性大脑中动脉闭塞模型的神经保护作用。
Crit Care Med. 2011 Jun;39(6):1448-53. doi: 10.1097/CCM.0b013e31821209be.
8
The therapeutic potential of carbon monoxide.一氧化碳的治疗潜力。
Nat Rev Drug Discov. 2010 Sep;9(9):728-43. doi: 10.1038/nrd3228.
9
Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury.氩气：在体外脑缺血和创伤性脑损伤模型中的神经保护作用。
Crit Care. 2009;13(6):R206. doi: 10.1186/cc8214. Epub 2009 Dec 17.
10
1,026 experimental treatments in acute stroke.1026种急性中风的实验性治疗方法。
Ann Neurol. 2006 Mar;59(3):467-77. doi: 10.1002/ana.20741.

Argon: a novel therapeutic option to treat neuronal ischemia and reperfusion injuries?

作者信息

Ulbrich Felix, Goebel Ulrich

机构信息

Department of Anesthesiology and Intensive Care Medicine, University Medical Center, Freiburg, Germany.

出版信息

Neural Regen Res. 2015 Jul;10(7):1043-4. doi: 10.4103/1673-5374.160071.

DOI:10.4103/1673-5374.160071
PMID:26330817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4541225/
Abstract
摘要