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膝关节镜下清创术:证据更新

Arthroscopic Debridement of the Knee: An Evidence Update.

出版信息

Ont Health Technol Assess Ser. 2014 Nov 1;14(13):1-43. eCollection 2014.

Abstract

BACKGROUND

Patients with knee pain as a result of osteoarthritis or degenerative meniscal injury may seek treatment through arthroscopic surgery. How effective arthroscopic debridement with or without meniscectomy is for relieving pain and improving patients' functional outcomes is uncertain.

OBJECTIVES

To conduct an evidence update of an evidence-based analysis (EBA) conducted in 2005 to determine if arthroscopic debridement for osteoarthritis of the knee or for meniscal injury from degenerative causes improve patient outcomes.

DATA SOURCES

A literature search was performed using Ovid MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, Embase, and all EBM databases, for studies published from January 1, 2005, to February 4, 2014.

REVIEW METHODS

A systematic review of the literature was conducted, limited to randomized controlled trials (RCTs) that examined the effectiveness of arthroscopic debridement with or without meniscectomy. Quality assessment of the body of literature was conducted using Grading of Recommendations Assessment, Development, and Evaluation (GRADE).

RESULTS

A total of 8 RCTs were identified, 2 from the original EBA plus 6 that were published since that time. The studies included patients with a range of indications for treatment and severity of osteoarthritis. Moderate-quality evidence showed no statistically significant difference in pain or functional status between patients who received arthroscopic treatment versus placebo (e.g., sham surgery). Low-quality evidence showed no statistically significant difference in pain or functional status between patients who received arthroscopic treatment versus usual care (e.g., physical therapy).

LIMITATIONS

Heterogeneity across the study populations, interventions, and reported measures limited the ability to calculate a summary effect estimate; however, all studies demonstrated consistency in their findings.

CONCLUSIONS

The evidence does not show the superiority of arthroscopic debridement with or without meniscectomy in patients with osteoarthritis of the knee or with meniscal injury from degenerative causes.

摘要

背景

因骨关节炎或退行性半月板损伤而导致膝关节疼痛的患者可能会寻求关节镜手术治疗。关节镜下清创术联合或不联合半月板切除术对于缓解疼痛及改善患者功能结局的效果尚不确定。

目的

对2005年进行的一项循证分析(EBA)进行证据更新,以确定膝关节骨关节炎或退行性病因导致的半月板损伤的关节镜下清创术是否能改善患者结局。

数据来源

使用Ovid MEDLINE、MEDLINE在研及其他未索引文献、Embase以及所有循证医学数据库进行文献检索,检索2005年1月1日至2014年2月4日发表的研究。

综述方法

对文献进行系统综述,限于考察关节镜下清创术联合或不联合半月板切除术有效性的随机对照试验(RCT)。采用推荐分级的评估、制定与评价(GRADE)对文献整体进行质量评估。

结果

共识别出8项RCT,其中2项来自原EBA,另外6项是此后发表的。这些研究纳入了具有一系列治疗指征和骨关节炎严重程度的患者。中等质量证据表明,接受关节镜治疗的患者与接受安慰剂(如假手术)的患者在疼痛或功能状态方面无统计学显著差异。低质量证据表明,接受关节镜治疗的患者与接受常规治疗(如物理治疗)的患者在疼痛或功能状态方面无统计学显著差异。

局限性

研究人群、干预措施及报告指标的异质性限制了计算汇总效应估计值的能力;然而,所有研究结果均具有一致性。

结论

证据未显示关节镜下清创术联合或不联合半月板切除术对于膝关节骨关节炎或退行性病因导致的半月板损伤患者具有优越性。

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