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KH-204对去势大鼠膀胱的保护作用

Protective Effects of KH-204 in the Bladder of Androgen-Deprived Rats.

作者信息

Bae Woong Jin, Ha U Syn, Choi Jin Bong, Kim Kang Sup, Kim Su Jin, Cho Hyuk Jin, Hong Sung Hoo, Lee Ji Youl, Wang Zhiping, Hwang Sung Yeoun, Kim Sae Woong

机构信息

Catholic Integrative Medicine Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

出版信息

World J Mens Health. 2015 Aug;33(2):73-80. doi: 10.5534/wjmh.2015.33.2.73. Epub 2015 Aug 19.

DOI:10.5534/wjmh.2015.33.2.73
PMID:26331123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4550599/
Abstract

PURPOSE

We investigated the protective effects of the herbal formulation KH-204 in the bladder of androgen-deprived rats.

MATERIALS AND METHODS

Male rats aged eight weeks were randomly divided into four groups, containing eight rats each: sham operation only (normal control group), androgen-deprived only (androgen-deprived control group), and androgen-deprived followed by treatment with 200 mg/kg or 400 mg/kg of KH-204. After 0.5 mg/kg of leuprorelin was subcutaneously injected in the androgen-deprived groups, the oral administration of either distilled water in the two control groups or KH-204 in the treatment group was continued for four weeks. Serum testosterone levels, RhoGEF levels, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, oxidative stress, and histologic changes were evaluated after treatment.

RESULTS

Treatment with the herbal formulation KH-204 (1) increased serum testosterone levels; (2) restored the expression of RhoGEFs, endothelial NO synthase, and neuronal NO synthase; (3) increased the expression of superoxide dismutase; and (4) decreased bladder fibrosis.

CONCLUSIONS

Our results suggest that the positive effects of KH-204 on the urinary bladder may be attributed to its antioxidant effects or to an elevation in NO-cGMP activity.

摘要

目的

我们研究了草药制剂KH - 204对去势大鼠膀胱的保护作用。

材料与方法

将8周龄雄性大鼠随机分为四组，每组8只：仅假手术组（正常对照组）、仅去势组（去势对照组），以及去势后分别用200mg/kg或400mg/kg KH - 204治疗组。在去势组皮下注射0.5mg/kg亮丙瑞林后，两个对照组继续口服蒸馏水，治疗组继续口服KH - 204，持续4周。治疗后评估血清睾酮水平、RhoGEF水平、一氧化氮（NO）-环磷酸鸟苷（cGMP）相关参数、氧化应激和组织学变化。

结果

草药制剂KH - 204治疗（1）提高了血清睾酮水平；（2）恢复了RhoGEF、内皮型一氧化氮合酶和神经元型一氧化氮合酶的表达；（3）增加了超氧化物歧化酶的表达；（4）减轻了膀胱纤维化。

结论

我们的结果表明，KH - 204对膀胱的积极作用可能归因于其抗氧化作用或NO - cGMP活性的升高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a220/4550599/8fbe9cb33735/wjmh-33-73-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a220/4550599/3e565bae0ed2/wjmh-33-73-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a220/4550599/0153f90435ef/wjmh-33-73-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a220/4550599/be42c26aba55/wjmh-33-73-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a220/4550599/e2467776a6db/wjmh-33-73-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a220/4550599/8fbe9cb33735/wjmh-33-73-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a220/4550599/3e565bae0ed2/wjmh-33-73-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a220/4550599/0153f90435ef/wjmh-33-73-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a220/4550599/be42c26aba55/wjmh-33-73-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a220/4550599/e2467776a6db/wjmh-33-73-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a220/4550599/8fbe9cb33735/wjmh-33-73-g005.jpg

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