Moon Hyong Woo, Park Jung Woo, Lee Kyu Won, Jeong Hyun Cheol, Choi Jin Bong, Choi Sae Woong, Bae Woong Jin, Cho Hyuk Jin, Ha U Syn, Hong Sung Hoo, Geum Jeong Ho, Hong Seong Bin, Kim Sae Woong
Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Catholic Integrative Medicine Research Institute, The Catholic University of Korea, Seoul, Korea.
World J Mens Health. 2017 Apr;35(1):43-50. doi: 10.5534/wjmh.2017.35.1.43. Epub 2016 Dec 22.
This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats.
Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each: a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined.
Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis.
Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.
本研究调查了枸杞（枸杞）对老年大鼠勃起功能障碍的影响。
使用24只18个月大的雄性Sprague-Dawley大鼠（定义为老年大鼠）。治疗组每组包含8只大鼠：一个对照组、150毫克/千克/天枸杞提取物组和300毫克/千克/天枸杞提取物组。通过灌胃管每天给药一次，持续6周。治疗6周后，检查睾丸重量、血清睾酮、超氧化物歧化酶、一氧化氮（NO）-环磷酸鸟苷（cGMP）相关参数、海绵体内压/平均动脉压以及组织学变化。
枸杞提取物治疗可提高血清睾酮水平，增加内皮型一氧化氮合酶、神经元型一氧化氮合酶和cGMP的表达，改善氧化应激标志物，并减少海绵体纤维化。
我们的结果表明，枸杞提取物可能通过其抗氧化作用对勃起功能障碍产生积极影响。
