National AIDS Reference Centre of Northern Greece, Department of Microbiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
1st Internal Medicine Department, Infectious Diseases Division, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Med Virol. 2016 Apr;88(4):724-7. doi: 10.1002/jmv.24369. Epub 2015 Sep 21.
Viral load testing is a valuable tool in HIV clinical care and research. Discrepancies among diverse viral load assays, especially with regard to non-B HIV-1 subtypes have been reported. Our study aimed to explore the impact of HIV subtype (B versus non-B) on the agreement between CAP/CTM, v2.0 and m2000 RealTime in treated HIV patients, focusing on low viral loads (<200 copies/ml). Our findings indicate that there is a significant difference in the performance of the compared assays in the low-viremic range and non-B subtypes, suggesting that a single assay should be used for follow-up.
病毒载量检测是 HIV 临床护理和研究中的一种有价值的工具。不同的病毒载量检测方法之间存在差异，尤其是在非 B 型 HIV-1 亚型方面，这一点已得到报道。我们的研究旨在探讨 HIV 亚型（B 型与非 B 型）对 CAP/CTM、v2.0 和 m2000 RealTime 在治疗中的 HIV 患者之间一致性的影响，重点关注低病毒载量（<200 拷贝/ml）。我们的研究结果表明，在低病毒载量范围内和非 B 亚型中，比较分析方法的性能存在显著差异，这表明应该使用单一的检测方法进行后续检测。
