Das U N, Ramadevi G, Rao K P, Rao M S
Department of Medicine, Nizam's Institute of Medical Sciences, Hyderabad, India.
Prostaglandins. 1989 Dec;38(6):689-716. doi: 10.1016/0090-6980(89)90050-6.
The effect of prostaglandin E1, E2, and F2 alpha on gamma-radiation, benzo(a)pyrene and diphenylhydantoin-induced cytotoxicity in vivo and genotoxicity in vitro was investigated. Prostaglandin E1 prevented both cytotoxic and genotoxic actions of all the three agents, where as both PGE2 and PGF2 alpha were ineffective. In fact, it was seen that both PGE2 and PGF2 alpha are genotoxic by themselves. Gamma-linolenic acid and dihomogamma-linolenic acid, the precursor of PGE1 were also as protective as that of PGE1, where as arachidonic acid, the precursor of 2 series PGs, has genotoxic actions to human lymphocytes in vitro. These results suggest that prostaglandins and their precursors can determine the susceptibility of cells to cytotoxic and genotoxic actions of chemicals and radiation. This study is particularly interesting since, it is known that some tumor cells contain excess of PGE2 and PGF2 alpha and many carcinogens can augment the synthesis of 2 series of PGs.
研究了前列腺素E1、E2和F2α对γ射线、苯并(a)芘和苯妥英在体内诱导的细胞毒性以及在体外诱导的遗传毒性的影响。前列腺素E1可预防这三种物质的细胞毒性和遗传毒性作用，而前列腺素E2和F2α均无效。事实上，可以看出前列腺素E2和F2α本身具有遗传毒性。γ-亚麻酸和二高γ-亚麻酸作为前列腺素E1的前体，其保护作用与前列腺素E1相同，而作为2系列前列腺素前体的花生四烯酸，在体外对人淋巴细胞具有遗传毒性作用。这些结果表明，前列腺素及其前体可以决定细胞对化学物质和辐射的细胞毒性和遗传毒性作用的敏感性。这项研究特别有趣，因为已知一些肿瘤细胞含有过量的前列腺素E2和F2α，而且许多致癌物可以增加2系列前列腺素的合成。
