Das U N, Ramadevi G, Rao K P, Rao M S
Prostaglandins. 1985 Jun;29(6):911-20. doi: 10.1016/0090-6980(85)90216-3.
Experiments were performed to study the effect of various prostaglandins (PGs) and their precursors, gamma-linolenic acid (GLA) and arachidonic acid (AA) on gamma-radiation and benzo (a) pyrene (BP)-induced genetic damage to the bone marrow cells of mice, using the sensitive micronucleus (MN) test. Thromboxane B2 prostaglandin E1 and GLA completely prevented BP-induced and reduced to a great degree radiation-induced genetic damage, where as PGE2, PGF2 alpha and AA were without any effect. Since GLA and AA are widely distributed in the cell membranes, and as PGs can be formed virtually in response to any type of stimulus, it is likely that GLA and PGE1 may function as endogenous anti-mutagenic chemicals.
进行了实验，以使用敏感的微核（MN）试验研究各种前列腺素（PGs）及其前体γ-亚麻酸（GLA）和花生四烯酸（AA）对γ辐射和苯并（a）芘（BP）诱导的小鼠骨髓细胞遗传损伤的影响。血栓素B2、前列腺素E1和GLA完全预防了BP诱导的遗传损伤，并在很大程度上减轻了辐射诱导的遗传损伤，而前列腺素E2、前列腺素F2α和AA则没有任何作用。由于GLA和AA广泛分布于细胞膜中，并且由于PGs实际上可以响应任何类型的刺激而形成，因此GLA和前列腺素E1可能作为内源性抗诱变化学物质发挥作用。
