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γ-亚麻酸和前列腺素E1对γ射线及化学物质诱导的小鼠骨髓细胞遗传损伤的影响。

Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice.

作者信息

Das Undurti N, Rao Kaipa P

机构信息

UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH 44120, USA.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 2006 Mar;74(3):165-73. doi: 10.1016/j.plefa.2006.01.002. Epub 2006 Feb 20.

DOI:10.1016/j.plefa.2006.01.002
PMID:16488586
Abstract

The effect of gamma-linolenic acid (GLA) and prostaglandin E1 (PGE1) on gamma-radiation, diphenylhydantoin (DPH), benzo(a)pyrene (BP), and 4-alpha-phorbol-induced genetic damage to the bone marrow cells of mice, using the sensitive micronucleus (MN) test was investigated. PGE1 and its precursor GLA prevented gamma-radiation, DPH, BP, and 4-alpha-phorbol-induced genetic damage.

摘要

使用敏感的微核（MN）试验，研究了γ-亚麻酸（GLA）和前列腺素E1（PGE1）对γ射线、苯妥英（DPH）、苯并(a)芘（BP）和4-α-佛波醇诱导的小鼠骨髓细胞遗传损伤的影响。PGE1及其前体GLA可预防γ射线、DPH、BP和4-α-佛波醇诱导的遗传损伤。

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