Teixeira André L, Ramos Plínio S, Vianna Lauro C, Ricardo Djalma R
Maternity Hospital Therezinha de Jesus, Faculty of Medical and Health Sciences-SUPREMA, Juiz de Fora, Brazil.
Postgraduate program, Exercise and Sports Sciences, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
Psychophysiology. 2015 Nov;52(11):1451-5. doi: 10.1111/psyp.12510. Epub 2015 Sep 2.
Previous studies have shown that resting heart rate variability (HRV) is modified by different phases of the menstrual cycle in nonusers of oral contraceptive pills (OCP); however, the effect of OCP on autonomic control of the heart remains unclear. The purpose of this study was to investigate HRV during the low hormone (LH-not taking OCP) and during the high hormone (HH-active OCP use) phases of the menstrual cycle in young women. Seventeen healthy women (19-31 years) taking OCP for at least 6 consecutive months were enrolled in this study. Plasma estradiol and progesterone were verified at each visit. HRV was assessed by using one-lead electrocardiography in time and frequency domains, in which participants rested in the supine position for a 20-min period with a breathing rate of 15 cycles/min. In addition, resting heart rate, and systolic and diastolic blood pressure were obtained. Both plasma estradiol (LH: 19.8 ± 4.2 pg/mL vs. HH: 12.4 ± 1.5 pg/mL; p > .05) and progesterone (LH: 0.247 ± 0.58 ng/mL vs. HH: 0.371 ± 0.08 ng/mL; p > .05) (mean ± SE) levels were similar in both phases. No significant difference was obtained for any component of HRV, heart rate, or blood pressure between the LH and HH phases (p > .05). These results provide preliminary evidence that use of OCP does not affect HRV during the menstrual cycle in healthy women.
先前的研究表明，在未服用口服避孕药（OCP）的女性中，静息心率变异性（HRV）会因月经周期的不同阶段而改变；然而，OCP对心脏自主控制的影响仍不清楚。本研究的目的是调查年轻女性月经周期中低激素（LH-未服用OCP）和高激素（HH-正在服用OCP）阶段的HRV。17名连续服用OCP至少6个月的健康女性（19-31岁）参与了本研究。每次就诊时均检测血浆雌二醇和孕酮水平。通过单导联心电图在时域和频域评估HRV，参与者仰卧休息20分钟，呼吸频率为每分钟15次。此外，还测量了静息心率、收缩压和舒张压。两个阶段的血浆雌二醇（LH：19.8±4.2 pg/mL vs. HH：12.4±1.5 pg/mL；p>.05）和孕酮（LH：0.247±0.58 ng/mL vs. HH：0.371±0.08 ng/mL；p>.05）（均值±标准误）水平相似。LH和HH阶段之间的HRV、心率或血压的任何组成部分均无显著差异（p>.05）。这些结果提供了初步证据，表明在健康女性月经周期中使用OCP不会影响HRV。
