Chemelli Angela, Conde-Valentín Beatriz, Uhlig Frank, Glatter Otto
Institute of Inorganic Chemistry, Graz University of Technology , Stremayrgasse 9, 8010 Graz, Austria.
Langmuir. 2015 Sep 29;31(38):10377-81. doi: 10.1021/acs.langmuir.5b02139. Epub 2015 Sep 15.
Self-assembled phases based on monoglycerides are promising candidates for drug delivery systems. Alterations of these phases need to be performed by addition of substances which are biocompatible. Inverse bicontinuous cubic phases are altered by the addition of five amino acids, namely, glycine, phenylalanine, alanine, glutamine, and tryptophan. These natural molecules have a diversity of side chains which predicts their polarity and subsequently their interaction with the interfacial region. Whereas polar amino acids cause a slight shrinking of the fully hydrated phase, amino acids with a nonpolar side chain expand it. Tryptophan is also able to provoke a growth of inverse hexagonal, micellar cubic, and micellar structures. Amino acid concentrations in the aqueous phase, even above the amino acid's solubility, further affect all aforementioned structures and cause a significant enlargement of up to 26%. Besides the amino acids' impact on the structural sizes, they also affect the phase transition temperatures.
基于甘油单酯的自组装相是药物递送系统的有前景的候选物。这些相的改变需要通过添加生物相容性物质来进行。通过添加五种氨基酸，即甘氨酸、苯丙氨酸、丙氨酸、谷氨酰胺和色氨酸，可以改变反相双连续立方相。这些天然分子具有多样的侧链，这预示了它们的极性以及随后它们与界面区域的相互作用。极性氨基酸会导致完全水合相略有收缩，而具有非极性侧链的氨基酸会使其膨胀。色氨酸还能够促使反相六方相、胶束立方相和胶束结构的生长。水相中氨基酸的浓度，即使高于氨基酸的溶解度，也会进一步影响上述所有结构，并导致高达26%的显著增大。除了氨基酸对结构尺寸的影响外，它们还会影响相变温度。
