在颞叶癫痫的锂-匹鲁卡品模型中，青春期大鼠的探索行为和空间记忆受损。
Impairment of exploratory behavior and spatial memory in adolescent rats in lithium-pilocarpine model of temporal lobe epilepsy.
作者信息
Kalemenev S V, Zubareva O E, Frolova E V, Sizov V V, Lavrentyeva V V, Lukomskaya N Ya, Kim K Kh, Zaitsev A V, Magazanik L G
机构信息
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
出版信息
Dokl Biol Sci. 2015;463:175-7. doi: 10.1134/S0012496615040055. Epub 2015 Sep 3.
Cognitive impairment in six-week -old rats has been studied in the lithium-pilocarpine model of adolescent temporal lobe epilepsy in humans. The pilocarpine-treated rats (n =21) exhibited (a) a decreased exploratory activity in comparison with control rats (n = 20) in the open field (OP) test and (b) a slower extinction of exploratory behavior in repeated OP tests. The Morris Water Maze (MWM) test showed that the effect of training was less pronounced in the pilocarpine-treated rats, which demonstrated disruption of predominantly short-term memory. Therefore, our study has shown that lithium-pilocarpine seizures induce substantial changes in exploratory behavior and spatial memory in adolescent rats. OP and MWM tests can be used in the search of drugs reducing cognitive impairments associated with temporal lobe epilepsy.
在人类青少年颞叶癫痫的锂-匹罗卡品模型中，对六周龄大鼠的认知障碍进行了研究。用匹罗卡品处理的大鼠（n = 21）在旷场（OP）试验中表现出：（a）与对照大鼠（n = 20）相比，探索活动减少；（b）在重复的OP试验中，探索行为的消退较慢。莫里斯水迷宫（MWM）试验表明，在经匹罗卡品处理的大鼠中，训练效果不太明显，这表明主要是短期记忆受到破坏。因此，我们的研究表明，锂-匹罗卡品诱发的癫痫发作会导致青春期大鼠的探索行为和空间记忆发生实质性变化。OP和MWM试验可用于寻找减轻与颞叶癫痫相关的认知障碍的药物。
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