Guarino Annunziata, Pignata Paola, Lovisari Francesca, Asth Laila, Simonato Michele, Soukupova Marie
Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Ferrara, Italy.
Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Front Neurol. 2024 May 30;15:1392977. doi: 10.3389/fneur.2024.1392977. eCollection 2024.
Patients with epilepsy are prone to cognitive decline, depression, anxiety and other behavioral disorders. Cognitive comorbidities are particularly common and well-characterized in people with temporal lobe epilepsy, while inconsistently addressed in epileptic animals. Therefore, the aim of this study was to ascertain whether there is good evidence of cognitive comorbidities in animal models of epilepsy, in particular in the rat pilocarpine model of temporal lobe epilepsy. We searched the literature published between 1990 and 2023. The association of spontaneous recurrent seizures induced by pilocarpine with cognitive alterations has been evaluated by using various tests: contextual fear conditioning (CFC), novel object recognition (NOR), radial and T-maze, Morris water maze (MWM) and their variants. Combination of results was difficult because of differences in methodological standards, in number of animals employed, and in outcome measures. Taken together, however, the analysis confirmed that pilocarpine-induced epilepsy has an effect on cognition in rats, and supports the notion that this is a valid model for assessment of cognitive temporal lobe epilepsy comorbidities in preclinical research.
癫痫患者容易出现认知能力下降、抑郁、焦虑等行为障碍。认知共病在颞叶癫痫患者中尤为常见且特征明显，而在癫痫动物模型中却未得到一致的研究。因此，本研究的目的是确定在癫痫动物模型中，尤其是在大鼠匹鲁卡品颞叶癫痫模型中，是否有关于认知共病的充分证据。我们检索了1990年至2023年发表的文献。通过使用各种测试评估了匹鲁卡品诱导的自发性反复癫痫发作与认知改变之间的关联：情境恐惧条件反射（CFC）、新物体识别（NOR）、放射状迷宫和T型迷宫、莫里斯水迷宫（MWM）及其变体。由于方法标准、所用动物数量和结果测量方面的差异，很难对结果进行综合分析。然而，综合来看，分析证实匹鲁卡品诱导的癫痫对大鼠认知有影响，并支持这是临床前研究中评估认知性颞叶癫痫共病的有效模型这一观点。
