Kalemenev S V, Zubareva O E, Sizov V V, Lavrent'eva V V, Lukomskaya N Ya, Kim K Kh, Zaitsev A V, Magazanik L G
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Institute of Experimental Medicine, St. Petersburg, Russia.
Dokl Biol Sci. 2016 Sep;470(1):224-227. doi: 10.1134/S0012496616050148. Epub 2016 Nov 8.
The capability of memantine, a noncompetitive antagonist of the NMDA receptors, to prevent impairments of cognitive functions in rats was investigated in the lithium-pilocarpine model of epilepsy. After status epilepticus, rats exhibited impaired exploratory behavior and spatial memory, and a decline of extinction of orienting behavior. Memantine administration prevented these disturbances. Thus, the blockade of the NMDA receptors immediately after status epilepticus allowed prevention of the development of the possible cognitive impairments.
在癫痫的锂-匹鲁卡品模型中，对N-甲基-D-天冬氨酸（NMDA）受体的非竞争性拮抗剂美金刚预防大鼠认知功能损害的能力进行了研究。癫痫持续状态后，大鼠表现出探索行为和空间记忆受损，以及定向行为消退能力下降。给予美金刚可预防这些障碍。因此，在癫痫持续状态后立即阻断NMDA受体可预防可能出现的认知功能损害的发展。
