Kuhns Lisa M, Reisner Sari L, Mimiaga Matthew J, Gayles Travis, Shelendich Michael, Garofalo Robert
Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital, 225 E. Chicago Avenue, Box 161, Chicago, IL, 60611, USA.
Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
AIDS Behav. 2016 Jul;20(7):1470-7. doi: 10.1007/s10461-015-1182-z.
Transgender women are at high risk of HIV infection, with younger transgender women (YTW) particularly vulnerable. Pre-Exposure Prophylaxis (PrEP) has shown efficacy in reducing HIV acquisition, but little is known about PrEP indication or initiation among YTW. Baseline data from 180 YTW age 18-29 years enrolled in Project LifeSkills, an on-going HIV prevention intervention for YTW, were analyzed to examine factors associated with PrEP indication. The sample (mean age = 23.4, SD = 3.2) was comprised largely of women of color (69 %) and of low socioeconomic status (71 % unemployed). Overall, 62 % met criteria for PrEP indication, but only 5 % reported ever taking PrEP. Factors associated with increased odds of PrEP indication were: PrEP interest (aOR 3.24; 95 % CI 1.44, 7.33), number of recent anal sex partners (aOR 1.23; 95 % CI 1.04, 1.46), and lower collective self-esteem scores (aOR 0.67; 95 % CI 0.47, 0.94). Despite high levels of PrEP indication, there remain low levels of PrEP awareness and uptake among YTW.
跨性别女性感染艾滋病毒的风险很高，年轻的跨性别女性（YTW）尤其脆弱。暴露前预防（PrEP）已显示出在减少艾滋病毒感染方面的有效性，但对于YTW中PrEP的指征或开始使用情况知之甚少。对参与“生活技能项目”（一项正在进行的针对YTW的艾滋病毒预防干预措施）的180名18 - 29岁的YTW的基线数据进行了分析，以检查与PrEP指征相关的因素。样本（平均年龄 = 23.4，标准差 = 3.2）主要由有色人种女性（69%）和社会经济地位较低（71%失业）的女性组成。总体而言，62%符合PrEP指征标准，但只有5%报告曾使用过PrEP。与PrEP指征几率增加相关的因素有：对PrEP的兴趣（调整后比值比[aOR] 3.24；95%置信区间[CI] 1.44，7.33）、近期肛交性伴侣数量（aOR 1.23；95% CI 1.04，1.46）以及较低的集体自尊得分（aOR 0.67；95% CI 0.47，0.94）。尽管PrEP指征水平较高，但YTW中PrEP的知晓率和使用率仍然较低。
