Mao Song, Yan Bin, Zhang Jianhua
a Department of Pediatrics , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , P.R. China and.
b Department of Geriatric Neurology , Jinling Hospital, Nanjing University School of Medicine , Nanjing , P.R. China.
Ren Fail. 2015 Nov;37(10):304-11. doi: 10.3109/0886022X.2015.1077324. Epub 2015 Aug 31.
The association of transforming growth factor-β1 (TGF-β1) polymorphisms with the risk of chronic kidney diseases (CKD) remains elusive. We aimed to perform a meta-analysis to evaluate the relationship between TGF-β1 polymorphisms and the susceptibility to CKD. Association studies were searched according to a defined criteria using electronic databases. The strength of association between TGF-β1 polymorphisms and CKD risk was evaluated by odds ratio (OR) with the corresponding 95% confidence interval (CI). Nine case-control studies were identified. T allele at the +869 T/C polymorphism was associated with a lower risk of CKD in Asians (p = 0.003). TT genotype at the +869 T/C polymorphism was associated with a lower risk of CKD in overall populations and Asians (p = 0.007 and <10(-4), respectively). CC genotype at the +869 T/C polymorphism was associated with the risk of CKD in Asians (p = 0.002). T allele at the -509 T/C polymorphism was associated with the risk of CKD in overall populations and Asians (p = 0.044 and 0.050, respectively). TT genotype at the -509 T/C polymorphism was associated with CKD risk in overall populations, Caucasians and Asians (p < 10(-4), <10(-4), and <10(-4), respectively). No evidence of significant publication bias was noted. In conclusion, T allele at the +869 T/C polymorphism may be a protective factor against CKD risk in Asians. TT genotype at the +869 T/C polymorphism may be an indicator of lower risk of CKD in overall populations and Asians. CC genotype at the +869 T/C polymorphism may predict the susceptibility to CKD in Asians. T allele at the -509 T/C polymorphism may be an indicator of CKD risk in overall populations and Asians. TT genotype at the -509 T/C polymorphism was a risk factor for CKD onset in overall populations, Caucasians and Asians.
转化生长因子-β1（TGF-β1）基因多态性与慢性肾脏病（CKD）风险之间的关联仍不明确。我们旨在进行一项荟萃分析，以评估TGF-β1基因多态性与CKD易感性之间的关系。根据既定标准，使用电子数据库检索相关的关联研究。通过比值比（OR）及相应的95%置信区间（CI）评估TGF-β1基因多态性与CKD风险之间的关联强度。共纳入9项病例对照研究。+869 T/C多态性位点的T等位基因与亚洲人较低的CKD风险相关（p = 0.003）。+869 T/C多态性位点的TT基因型与总体人群和亚洲人较低的CKD风险相关（分别为p = 0.007和<10⁻⁴）。+869 T/C多态性位点的CC基因型与亚洲人CKD风险相关（p = 0.002）。-509 T/C多态性位点的T等位基因与总体人群和亚洲人CKD风险相关（分别为p = 0.044和0.050）。-509 T/C多态性位点的TT基因型与总体人群、白种人和亚洲人的CKD风险相关（分别为p < 10⁻⁴、<10⁻⁴和<10⁻⁴）。未发现明显的发表偏倚证据。总之，+869 T/C多态性位点的T等位基因可能是亚洲人CKD风险的保护因素。+869 T/C多态性位点的TT基因型可能是总体人群和亚洲人CKD风险较低的指标。+869 T/C多态性位点的CC基因型可能预测亚洲人对CKD的易感性。-509 T/C多态性位点的T等位基因可能是总体人群和亚洲人CKD风险的指标。-509 T/C多态性位点的TT基因型是总体人群以及白种人和亚洲人CKD发病的危险因素。
