Mai Meifang, Jiang Yinlian, Wu Xiaoman, Liu Gengrong, Zhu Yaoli, Zhu Weiping
Nephrology Division, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Intensive Care Unit, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
Front Genet. 2020 Feb 27;11:79. doi: 10.3389/fgene.2020.00079. eCollection 2020.
Anti-inflammatory cytokine polymorphisms in the transforming growth factor-β1 (), interleukin-4 (), and genes have been implicated as risk factors for chronic kidney disease (CKD), but the results from published studies are inconsistent. Our meta-analysis reviews and summarizes the cumulative evidence for these associations.
A systematic literature search of five databases was performed up to October 2019. Two authors independently extracted data and evaluated the quality of included studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were generated from random-effects or fixed-effects models using Stata 12.0.
Nineteen studies from 10 countries satisfied our inclusion criteria and were included in the meta-analysis. Overall, the pooled analysis showed that rs1800469 was associated with decreased susceptibility to CKD (CC + TC . TT, OR = 0.33, 95% CI: 0.15-0.76, P = 0.009; CC . TT, OR = 0.33, 95% CI: 0.15-0.73, P = 0.006), whereas rs1800471 was associated with increased CKD susceptibility (CC . CG + GG, OR = 1.68, 95% CI: 1.02-2.77, P = 0.041). In stratified analyses based on ethnicity, rs1800469 was associated with CKD susceptibility in Asians and Caucasians, and there was an association of rs1800470 and rs8179190 with CKD in Asians. Stratified analyses also associated rs1800471 with CKD susceptibility in Caucasians. Neither overall meta-analyses nor stratified analyses identified an association of the rs1800869 and rs1800871 polymorphisms with susceptibility to CKD.
Available data suggest that common polymorphisms in the and genes including rs1800469, rs1800470, rs1800471, and rs8179190 may be important genetic contributors to CKD susceptibility.
转化生长因子-β1（TGF-β1）、白细胞介素-4（IL-4）和IL-10基因中的抗炎细胞因子多态性被认为是慢性肾脏病（CKD）的危险因素，但已发表研究的结果并不一致。我们的荟萃分析回顾并总结了这些关联的累积证据。
截至2019年10月，对五个数据库进行了系统的文献检索。两位作者独立提取数据并评估纳入研究的质量。使用Stata 12.0从随机效应或固定效应模型生成合并优势比（OR）和95%置信区间（CI）。
来自10个国家的19项研究符合我们的纳入标准并被纳入荟萃分析。总体而言，合并分析显示TGF-β1 rs1800469与CKD易感性降低相关（CC + TC对TT，OR = 0.33，95%CI：0.15 - 0.76，P = 0.009；CC对TT，OR = 0.33，95%CI：0.15 - 0.73，P = 0.006），而IL-10 rs1800471与CKD易感性增加相关（CC对CG + GG，OR = 1.68，95%CI：1.02 - 2.77，P = 0.041）。在基于种族的分层分析中，TGF-β1 rs1800469与亚洲人和高加索人的CKD易感性相关，并且IL-4 rs1800470和IL-10 rs8179190与亚洲人的CKD相关。分层分析还显示IL-10 rs1800471与高加索人的CKD易感性相关。总体荟萃分析和分层分析均未发现IL-4 rs1800869和rs1800871多态性与CKD易感性之间存在关联。
现有数据表明，TGF-β1和IL-10基因中的常见多态性，包括rs1800469、rs1800470、rs1800471和rs8179190，可能是CKD易感性的重要遗传因素。
