通过可见光照射和有机金属铝实现哌嗪的可扩展合成。
Scalable Synthesis of Piperazines Enabled by Visible-Light Irradiation and Aluminum Organometallics.
作者信息
Suárez-Pantiga Samuel, Colas Kilian, Johansson Magnus J, Mendoza Abraham
机构信息
Department of Organic Chemistry and Berzelii EXSELENT Center for Porous Materials, Stockholm University, Arrhenius Laboratory, 10691 Stockholm (Sweden) http://www.organ.su.se/am/
Innovative Medicines, Cardiovascular and Metabolic Diseases, Medicinal Chemistry, AstraZeneca R&D, Pepparedsleden 1, 43183 Mölndal (Sweden).
出版信息
Angew Chem Int Ed Engl. 2015 Nov 16;54(47):14094-8. doi: 10.1002/anie.201505608. Epub 2015 Sep 4.
The development of more active C-H oxidation catalysts has inspired a rapid, scalable, and stereoselective assembly of multifunctional piperazines through a [3+3] coupling of azomethine ylides. A combination of visible-light irradiation and aluminum organometallics is essential to promote this transformation, which introduces visible-light photochemistry of main-group organometallics and sets the basis for new and promising catalysts.
更具活性的C-H氧化催化剂的开发，通过甲亚胺叶立德的[3+3]偶联反应，激发了多功能哌嗪的快速、可扩展且立体选择性的组装。可见光照射和有机金属铝的组合对于促进这种转化至关重要，这引入了主族有机金属的可见光光化学，并为新型且有前景的催化剂奠定了基础。
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