健康成人疫苗接种：中国预防乙型肝炎的迫切需求。
Healthy adult vaccination: An urgent need to prevent hepatitis B in China.
作者信息
Qiu Yan, Ren Jingjing, Yao Jun
机构信息
a General Practice Department , the First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
b Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
出版信息
Hum Vaccin Immunother. 2016 Mar 3;12(3):773-8. doi: 10.1080/21645515.2015.1086519.
Abstract
Prevalence of hepatitis B is still high among adults in China, athough the prevalence in children has decreased dramatically. Immunization against hepatitis B among adults is urgently required. Through analyzing the immunogenicity of different doses, schedules and booster immunization among adults, we recommend 10 or 20 μg with a 0-1-6-month schedule or a 0-1-12-month schedule for migrant adults. For immunity failure, increasing the dose or covalent vaccine is suggested to provide protective antibodies. To enhance immunity among adults, hepatitis B vaccine should be included in health insurance.
摘要
在中国，成人乙肝感染率仍居高不下，尽管儿童感染率已大幅下降。成人急需接种乙肝疫苗。通过分析成人不同剂量、接种程序和加强免疫的免疫原性，我们建议流动成人采用0-1-6月或0-1-12月程序接种10或20微克疫苗。对于免疫失败的情况，建议增加剂量或使用重组疫苗以产生保护性抗体。为增强成人免疫力，乙肝疫苗应纳入医保。
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