Dennehy Penelope H
Division of Pediatric Infectious Diseases, Department of Pediatrics, Hasbro Children's Hospital, 593 Eddy Street, Providence, RI 02903, USA.
Infect Dis Clin North Am. 2015 Dec;29(4):617-35. doi: 10.1016/j.idc.2015.07.002. Epub 2015 Sep 1.
Rotavirus infection is the most common cause of severe diarrhea disease in infants and young children worldwide. Vaccination is the only control measure likely to have a significant impact on the incidence of severe disease. Rotavirus vaccines have reduced the burden of disease in the United States and Europe and vaccine programs are being introduced in Asia and Africa where it is hoped that vaccine will have significant impact on severe infection. Long-term monitoring and strain surveillance are needed to assess the effects of rotavirus immunization programs and to determine whether changes in strain ecology will affect rotavirus vaccine effectiveness.
轮状病毒感染是全球婴幼儿严重腹泻疾病的最常见病因。接种疫苗是唯一有可能对严重疾病发病率产生重大影响的控制措施。轮状病毒疫苗已减轻了美国和欧洲的疾病负担，亚洲和非洲也正在推行疫苗接种计划，有望通过疫苗对严重感染产生重大影响。需要进行长期监测和毒株监测，以评估轮状病毒免疫计划的效果，并确定毒株生态的变化是否会影响轮状病毒疫苗的效力。
