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对一名因MYH7基因突变导致家族性肥厚型心肌病的胎儿进行宫内治疗。

Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation.

作者信息

Hill Meghan G, Sekhon Mehtab K, Reed Kathryn L, Anderson Caroline F, Borjon Nydia D, Tardiff Jil C, Barber Brent J

机构信息

Department of Obstetrics and Gynecology, The University of Arizona, College of Medicine, 1501 N. Campbell Ave, 8th Floor, Tucson, AZ, 85724, USA.

出版信息

Pediatr Cardiol. 2015 Dec;36(8):1774-7. doi: 10.1007/s00246-015-1250-1. Epub 2015 Sep 4.

DOI:10.1007/s00246-015-1250-1
PMID:26337809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4655206/
Abstract

There is no clear consensus on optimal management of fetuses affected by familial hypertrophic cardiomyopathy (HCM). Intrauterine treatment of the condition has not been attempted in any standardized fashion. We report the case of a fetus treated by maternal propranolol during the third trimester after septal hypertrophy and diastolic dysfunction was diagnosed on fetal echocardiogram. The pregnancy went successfully to term, and fetal septal hypertrophy was noted to improve prior to delivery.

摘要

对于受家族性肥厚型心肌病（HCM）影响的胎儿的最佳管理，目前尚无明确的共识。尚未以任何标准化方式尝试对该病症进行宫内治疗。我们报告了一例胎儿在孕晚期经母亲服用普萘洛尔治疗的病例，该胎儿经胎儿超声心动图诊断为室间隔肥厚和舒张功能障碍。妊娠顺利足月，并且在分娩前发现胎儿室间隔肥厚有所改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a13d/4655206/98391f20305b/246_2015_1250_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a13d/4655206/3838e8e2148b/246_2015_1250_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a13d/4655206/d18464797790/246_2015_1250_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a13d/4655206/98391f20305b/246_2015_1250_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a13d/4655206/3838e8e2148b/246_2015_1250_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a13d/4655206/d18464797790/246_2015_1250_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a13d/4655206/98391f20305b/246_2015_1250_Fig3_HTML.jpg

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