[长链脂酰辅酶A在心肌氧化磷酸化紊乱中的作用]
[The role of long-chain acyl-CoA in the disturbances of oxidative phosphorylation in the myocardium].
作者信息
Borutaĭte V I, Mildazhene V Iu, Ivanovene L I, Kholodenko B N, Toleĭkis A I, Prashkiavichius A K
出版信息
Biokhimiia. 1989 Dec;54(12):1947-51.
PMID:2633800
Abstract
The effect of intramitochondrial acyl-CoA on the respiration of rabbit heart mitochondria in different metabolic states was studied. Acyl-CoA inhibited O2 consumption by 11% in State 4 and by 6% in State 3. However, the effect of acyl-CoA was more pronounced (20%) in the intermediate state of respiration between State 4 and State 3. The data obtained suggest that acyl-CoA can regulate oxidative phosphorylation in heart mitochondria in vivo.
摘要
研究了线粒体内酰基辅酶A对处于不同代谢状态的兔心脏线粒体呼吸的影响。酰基辅酶A在状态4下抑制氧气消耗11%，在状态3下抑制6%。然而，酰基辅酶A在状态4和状态3之间的中间呼吸状态下的作用更为显著（20%）。所获得的数据表明，酰基辅酶A可以在体内调节心脏线粒体的氧化磷酸化。
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