Nazir Lubna, Rehman Shafique, Riaz Amir, Saeed Mohammad, Perveen Tahira
Department of Rheumatology, Liaquat National Hospital, Karachi.
J Pak Med Assoc. 2015 Sep;65(9):973-7.
To determine the frequency and risk factors of low bone mineral density in patients with spondyloarthropathies.
The cross-sectional study was conducted at the Rheumatology Department of a tertiary care hospital in Karachi between June and November 2014, and comprised spondyloarthritis patients whose bone mineral density of lumbar spine and hips was measured using dual energy X-ray absorptiometry scan. Variables like disease duration, diagnosis, human leukocyte antigen subtype B27, erythrocyte sedimentation rate, C-reactive protein, Bath ankylosing spondylitis disease activity Index, Bath ankylosing spondylitis functional index, Bath ankylosing spondylitis metrology index were measured along with outcomes, differentiating between osteopenia and/or osteoporosis. SPSS 21 was used for statistical analysis.
Of the 25 patients in the study, 16(64%) were males, 19(76%) had predominant axial involvement, and 20(80%) had duration of disease less than 10 years. Low bone mineral density at the spine and hip was found in 18(72%). Osteopenia was present in 9(36%) at hip and 8(32%)in spine, while osteoporosis was seen in 5(20%) at hip and 9(36%) in the spine. No significant association was found between bone mineral density and all the other parameters measured (p>0.05 each).
Majority of spondyloarthritis patients had decreased bone mineral density which could be observed in early stages of the disease.
确定脊柱关节病患者低骨密度的发生率及危险因素。
本横断面研究于2014年6月至11月在卡拉奇一家三级护理医院的风湿科进行，纳入了使用双能X线吸收法扫描测量腰椎和髋部骨密度的脊柱关节炎患者。测量了疾病持续时间、诊断、人类白细胞抗原B27亚型、红细胞沉降率、C反应蛋白、巴斯强直性脊柱炎疾病活动指数、巴斯强直性脊柱炎功能指数、巴斯强直性脊柱炎计量指数等变量以及结果，区分骨质减少和/或骨质疏松症。使用SPSS 21进行统计分析。
研究中的25例患者中，16例（64%）为男性，19例（76%）主要为轴向受累，20例（80%）疾病持续时间小于10年。18例（72%）患者在脊柱和髋部存在低骨密度。髋部骨质减少9例（36%），脊柱骨质减少8例（32%），髋部骨质疏松5例（20%），脊柱骨质疏松9例（36%）。未发现骨密度与所测量的所有其他参数之间存在显著关联（各p>0.05）。
大多数脊柱关节炎患者骨密度降低，在疾病早期即可观察到。
