Gemoll Timo, Meyer Rüdiger, Habermann Jens K
Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University of Lx00FC;beck and University Medical Center Schleswig-Holstein (UKSH), Lx00FC;beck, Germany.
Eur Surg Res. 2015;55(3):184-97. doi: 10.1159/000438860. Epub 2015 Sep 5.
Translational surgical research can range from investigating clinically oriented basic pathophysiological research via the correlation of molecular findings with a patient's clinical outcome to conducting treatment response studies. Herein, the specialist's opinion as a 'surgeon scientist' plays a pivotal role, e.g. in planning experimental setups focusing on the clinically most relevant needs. SUMMARY AND KEY MESSAGES: This review provides a survey of genomic and proteomic technologies and gives an up-to-date overview of those studies applying these technologies exemplarily in colorectal cancer-based biomarker research. Although current results are promising, future validation studies within multicenter networks are required to promote the translation of 'omics' from bench to bedside. In this endeavor, departments of surgery and institutes of experimental surgery together should play a fundamental role. The program for 'clinician scientists' recently launched by the German Research Society (DFG) could be one tool to promote interdisciplinary networks and surgeons' impact on translational research.
转化性外科研究的范围涵盖从通过分子研究结果与患者临床结局的相关性来开展以临床为导向的基础病理生理学研究，到进行治疗反应研究。在此过程中，作为“外科科学家”的专家意见起着关键作用，例如在规划聚焦临床最相关需求的实验设置方面。总结与关键信息：本综述对基因组学和蛋白质组学技术进行了概述，并对那些在基于结直肠癌的生物标志物研究中示例性应用这些技术的研究进行了最新综述。尽管当前结果很有前景，但仍需要在多中心网络中开展未来的验证研究，以推动“组学”从实验室到临床的转化。在这一努力中，外科科室和实验外科研究所应共同发挥基础性作用。德国研究基金会（DFG）最近启动的“临床医生科学家”项目可能是促进跨学科网络以及外科医生对转化研究产生影响的一种工具。
