UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia.
UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia.
J Proteomics. 2018 Sep 15;187:93-105. doi: 10.1016/j.jprot.2018.06.014. Epub 2018 Jun 25.
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Biomarkers that can facilitate better clinical management of CRC are in high demand to improve patient outcome and to reduce mortality. In this regard, proteomic analysis holds a promising prospect in the hunt of novel biomarkers for CRC and in understanding the mechanisms underlying tumorigenesis. This review aims to provide an overview of the current progress of proteomic research, focusing on discovery and validation of diagnostic biomarkers for CRC. We will summarize the contributions of proteomic strategies to recent discoveries of protein biomarkers for CRC and also briefly discuss the potential and challenges of different proteomic approaches in biomarker discovery and translational applications.
结直肠癌（CRC）是全球最常见的恶性肿瘤之一。为了改善患者预后和降低死亡率，人们迫切需要能够更好地进行 CRC 临床管理的生物标志物。在这方面，蛋白质组学分析在寻找 CRC 的新型生物标志物和理解肿瘤发生机制方面具有广阔的前景。本综述旨在概述蛋白质组学研究的最新进展，重点介绍 CRC 诊断生物标志物的发现和验证。我们将总结蛋白质组学策略对 CRC 蛋白生物标志物的最新发现的贡献，还将简要讨论不同蛋白质组学方法在生物标志物发现和转化应用中的潜力和挑战。
