Synthesis and biological activity of a cyclic hexapeptide related to peptide T.
作者信息
Bianchi S, Scaranari V, Tomatis R
机构信息
Dipartimento Scienze Farmaceutiche, Università di Ferrara, Italy.
出版信息
Farmaco. 1989 Dec;44(12):1233-7.
PMID:2634409
Abstract
The cyclo [Thr-Thr-Thr-Tyr-Asn-Thr] hexapeptide related to peptide T, H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, competitor of the Human Immunodeficiency Virus in the binding to human T cells, was synthesized and tested for its ability to stimulate monocyte migration (chemotaxis). The new cyclic derivative showed negligible biological activity.
摘要
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