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Synthesis and biological activity of a cyclic hexapeptide related to peptide T.

作者信息

Bianchi S, Scaranari V, Tomatis R

机构信息

Dipartimento Scienze Farmaceutiche, Università di Ferrara, Italy.

出版信息

Farmaco. 1989 Dec;44(12):1233-7.

PMID:2634409
Abstract

The cyclo [Thr-Thr-Thr-Tyr-Asn-Thr] hexapeptide related to peptide T, H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, competitor of the Human Immunodeficiency Virus in the binding to human T cells, was synthesized and tested for its ability to stimulate monocyte migration (chemotaxis). The new cyclic derivative showed negligible biological activity.

摘要

相似文献

1
Synthesis and biological activity of a cyclic hexapeptide related to peptide T.
Farmaco. 1989 Dec;44(12):1233-7.
2
Synthesis and activity of new linear and cyclic peptide T derivatives.
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Synthesis and biological activity of chelator-peptide T conjugates.螯合剂-肽T缀合物的合成与生物活性
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Synthesis and biological activity of D-glucopyranosyl peptide T derivatives.D-吡喃葡萄糖基肽T衍生物的合成及生物活性
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Correlation of the conformation of a modified ribonuclease octapeptide, homologous to peptide T, with its ability to induce CD4-dependent monocyte chemotaxis.
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Synthesis, metabolic stability and chemotactic activity of peptide T and its analogues.肽T及其类似物的合成、代谢稳定性和趋化活性。
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8
Conformational analysis of peptide T and of its C-pentapeptide fragment.肽T及其C末端五肽片段的构象分析。
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[Theoretical study of the spatial structure of the Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr segment of the HIV gp120 protein, responsible for binding of the virus with the T-cell T4 receptor].
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Structure-activity relationships of cyclic and linear peptide T analogues.
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